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IC_EX:G16B* AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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Analysis

1.20190180846SYSTEM AND METHOD FOR ANALYSIS OF BIOLOGICAL DATA
US 13.06.2019
Int.Class G16B 40/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
20Supervised data analysis
Appl.No 16324562 Applicant MeMed Diagnostics Ltd. Inventor Kfir OVED

A method of analyzing biological data is disclosed. The method comprises obtaining biological data containing at least an expression level of MX dynamin-like GTPase 1 (MX1) and an expression level of C-reactive protein (CRP) in the blood of a subject, calculating a distance between a segment of a curved line and an axis defined by a direction, the distance being calculated at a point over the curved line defined by a coordinate along the direction, and correlating the distance to the presence of, absence of, or likelihood that the subject has, a bacterial infection.

2.20200020420Method for Establishing Machine Learning Model for Predicting Toxicity of siRNA to Certain Type of Cells and Application Thereof
US 16.01.2020
Int.Class G16B 40/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
20Supervised data analysis
Appl.No 16465303 Applicant Hangzhou Converd Co., Ltd. Inventor Jinlu Cai

Provided is a method of establishing a machine learning model for predicting toxicity of siRNA to certain type of cells and application thereof. The method includes A) providing n siRNAs of 19-29 bp, wherein n≥2; B) obtaining input and output values for establishing the model from each siRNA, the input values being obtained by i) aligning each siRNA with genomic mRNAs and selecting complementary off-target genes having no more than 7 mismatched bases; ii) obtaining off-target weights according to mismatched bases' characteristic and mRNA's secondary structure in complementary region; iii) obtaining omic weights of the off-target genes using databases; iv) calculating omic eigenvalues as the input values, based on omic and off-target weights of all the off-target genes; the output values being obtained by conducting experiments with the siRNAs to obtain cell survival indexes; and C) calculating the input and output values of the n siRNAs through machine learning algorithm.

3.WO/2019/232357METHODS FOR COMPARATIVE METAGENOMIC ANALYSIS
WO 05.12.2019
Int.Class C12Q 1/6888
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
Appl.No PCT/US2019/034885 Applicant ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA Inventor HURWITZ, Bonnie L.
Systems and methods for metagenomic analysis are provided. A method of metagenome sequence analysis of two or more samples can include (i) counting the abundance of each k-mer deconstructed from sequencing reads of nucleic acids in each sample, and (ii) using a vector space model to compute the genetic distance between each of the two or more samples according to the abundance of the k-mers. In some embodiments, counting includes (a) constructing a k-mer histogram containing the distribution of k-mers for each sample, and (b) dividing k-mers into partitions having approximately an equal number of k-mers based on the histogram, preparing an inverted index of the k-mers in each partition, and assigning a weight to each k-mer according to its abundance. Method of developing diagnostic and prognostic information using the methods of sequence analysis are also provided.
4.20190275101STRUCTURE OF GII.4 NOROVIRUS PROTEASE - DESIGN OF BROAD-SPECTRUM PROTEASE INHIBITORS
US 12.09.2019
Int.Class A61K 38/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
Appl.No 16335349 Applicant Baylor College of Medicine Inventor B. Venkataram Prasad

The present disclosure concerns inhibitors of Norovirus protease that are suitable for use against any genotype of Norovirus, including at least GII.4 Norovirus proteases. In particular embodiments, specific compositions are encompassed, including their use for prevention or treatment of Norovirus infection in an individual.

5.2016209478Systems and methods for response prediction to chemotherapy in high grade bladder cancer
AU 28.07.2016
Int.Class G16B 20/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
Appl.No 2016209478 Applicant Nantomics, LLC Inventor
Contemplated systems and methods allow for prediction of chemotherapy outcome for patients diagnosed with high-grade bladder cancer. In particularly preferred aspects, the prediction is performed using a model based on machine learning wherein the model has a minimum predetermined accuracy gain and wherein a thusly identified model provides the identity and weight factors for omics data used in the outcome prediction.
6.3477648BIOLOGICAL SEQUENCE FINGERPRINTS
EP 01.05.2019
Int.Class G16B 20/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
Appl.No 18202170 Applicant DASSAULT SYSTEMES AMERICAS CORP Inventor KERMAN IAN M
In accordance with one embodiment of the invention, features of biological sequences are represented in a fingerprint that includes a bitset, and may also include counts, strings or continuous values, for the features. The fingerprint can be used with machine learning and statistical methods. This is especially advantageous for, though not limited to, drug discovery processes. The method permits Structure-Activity Relationship (SAR) and Quantitative Structure-Activity Relationship (QSAR) studies to be performed with biological sequences.
7.20200017926CELL-FREE NUCLEIC ACIDS FOR THE ANALYSIS OF THE HUMAN MICROBIOME AND COMPONENTS THEREOF
US 16.01.2020
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 16554286 Applicant The Board of Trustees of the Leland Stanford Junior University Inventor Iwijn de Vlaminck

Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with an therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.

8.20150133391Cell-free nucleic acids for the analysis of the human microbiome and components thereof
US 14.05.2015
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 14536300 Applicant The Board of Trustees of the Leland Stanford Junior University Inventor Iwijn de Vlaminick

Methods, devices, compositions and kits are provided for analysis of the microbiome or individual components thereof in an individual. The methods find use in a determination of infection, in analysis of the microbiome structure, in determining the immunocompetence of an individual, and the like. In some embodiments of the invention, the individual is treated with a therapeutic regimen, e.g. drugs, diet, radiation therapy, and the like.

9.20200176079METHODS AND DEVICES FOR NUCLEIC ACID-BASED REAL-TIME DETERMINATION OF DISEASE STATES
US 04.06.2020
Int.Class G16B 30/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
30ICT specially adapted for sequence analysis involving nucleotides or amino acids
Appl.No 16631523 Applicant Noscendo GmbH Inventor Philip Stevens

The present invention is directed to methods and devices for real-time diagnosis of disease states in subjects, for example, infections caused by one or more microorganisms or cancer.

10.20190359990VIRAL SYNTHETIC NUCLEIC ACID SEQUENCES AND USE THEREOF
US 28.11.2019
Int.Class C12N 15/67
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
Appl.No 16480671 Applicant SYNVACCINE LTD. Inventor Tamir TULLER

Nucleic acid molecules comprising a coding sequence with at least one codon substituted to a synonymous codon, a modified form of a virus comprising the nucleic acid molecules of the invention, and methods for producing these nucleic acid molecules, and viruses, are provided.