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IC:G01N33/569

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1.WO/2020/139620BIOMARKERS OF NEUTROPHIL DEREGULATION AS DIAGNOSTIC FOR GINGIVITIS
WO 02.07.2020
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No PCT/US2019/066813 Applicant COLGATE-PALMOLIVE COMPANY Inventor ZENOBIA, Camille
Methods of determining one or more ratios of chemokines in gingival crevicular fluid of an individual selected from the group consisting of: MIF:MIP1a, MIF:CXCL1; MIF:CXCL5; MIF:CXCL8; MIF:CXCL2; and MIF:CXCL6 and methods of identifying an individual as having gingivitis comprising determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Methods of treating individuals who are identified as having gingivitis by determining one or more ratios of the chemokines in gingival crevicular fluid are disclosed. Also disclosed are methods of monitoring the treatment individuals who have gingivitis.
2.WO/2020/135318APPLICATION OF CD38 INHIBITOR IN PREPARATION OF ANTI-RHEUMATOID ARTHRITIS DRUG
WO 02.07.2020
Int.Class A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
Appl.No PCT/CN2019/127369 Applicant HUBEI ATALENT BIOPHARMA TECHNOLOGY CO., LTD Inventor CHANG, Xiaotian
Provided is an application of a CD38 inhibitor in the preparation of an anti-rheumatoid arthritis (RA) drug. Studies have shown that the CD38+NK cell content and the ratio of CD38+NK / CD38+NKT in the blood and synovial fluid of an RA patient are increased, and such change is positively correlated with the DAS28 of the patient, indicating that CD38+NK cells and CD38+NKT cells are expected to become the therapeutic target of RA. Further research clearly shows that high levels of CD38+NK and a high ratio of CD38+NK / CD38+NKT in RA can reduce TGF-β secretion and activate the mTOR pathway of CD4+T cells in MNC, inhibiting the differentiation of CD4+T cells to differentiate Treg cells and IL-10 expression, increase the level of IFN-γ and the ratios of Thl/Th2 and Thl7/Treg, resulting in reduced anti-inflammatory and immune tolerance and exacerbating the course of RA.
3.WO/2020/138965METHOD FOR DIAGNOSIS OF PERIODONTAL DISEASE, AND COMPOSITION AND KIT THEREFOR
WO 02.07.2020
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No PCT/KR2019/018497 Applicant SUGENTECH, INC. Inventor KIM, Eunkyung
The present invention relates to a method for diagnosis of a periodontal disease. More particularly, a periodontal disease is diagnosed when an inflammatory disease marker including MMP-8, or a marker derived from a periodontal disease-causing strain is detected at an increased concentration, compared to a sample from a normal control. The detection of MMP-8 is separately performed for active MMP-8 and inactive MMP-8, whereby a diagnosis method and a composition and kit for diagnosis or prognosis prediction, which are of high accuracy, can be provided.
4.WO/2020/139142TESTING SYSTEM FOR DETERMINING THE ENZYMATIC ACTIVITY OF BACTERIA ON AMMONIA
WO 02.07.2020
Int.Class C12M 1/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
Appl.No PCT/RU2019/000906 Applicant "ASSOCIATION OF MEDICINE AND ANALYTICS" CO. LTD (AMA CO. LTD) Inventor DMITRIENKO, Marina Alexandrovna
The invention relates to the field of biotechnology. A testing system is proposed for determining the enzymatic activity of bacteria on ammonia. The testing system comprises: a support having a reactive element; a fixing plate on said support, which plate has an opening for accommodating biological material; and a cover plate on the fixing plate. The reactive element consists of an opaque indicator layer comprising an ammonia-sensitive indicator and consists of a sensitive layer which comprises a substrate for detecting enzymatic activity and which constitutes a semi-permeable, hydrophobic membrane. Furthermore, the surfaces of the support and the fixing plate which face each other are connected by an adhesive layer, and the area of the sensitive layer of the element is greater than the area of the indicator layer. Moreover, the support, the fixing plate and the cover plate are made from an impermeable, hydrophobic material, and their thickness and also the thickness of each of the layers of the reactive element are each between 50 and 300 micrometres. The invention reduces the time for determining the activity of enzymatic reactions, and expands the samples that can be investigated.
5.WO/2020/134306ANTIBODY AGAINST PAN-SPECIES-SPECIFIC PLASMODIUM LACTATE DEHYDROGENASE
WO 02.07.2020
Int.Class C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40against enzymes
Appl.No PCT/CN2019/109790 Applicant DONGGUAN PENGZHI BIOTECHNOLOGY CO., LTD. Inventor CUI, Peng
Provided are an isolated binding protein comprising pan-species-specific plasmodium lactate dehydrogenase antigen binding domain and a preparation method therefor. The antigen binding domain comprises at least one complementarity determining region selected from a defined amino acid sequence, or has sequence identity of at least 80% to the complementarity determining region of the following amino acid sequence and affinity of K D≤1.5647×10 -9mol/L for pan-species-specific plasmodium lactate dehydrogenase, and can identify the pan-species-specific plasmodium lactate dehydrogenase. The binding protein can be applied to the field of detection of plasmodium lactate dehydrogenase proteins.
6.3674708METHODS, SYSTEMS, AND DEVICES FOR DETECTING AND IDENTIFYING MICROORGANISMS IN MICROBIOLOGICAL CULTURE SAMPLES
EP 01.07.2020
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No 20157243 Applicant BECTON DICKINSON CO Inventor WEIDEMAIER KRISTIN
Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.
7.3674422SYSTEMS AND METHODS FOR DETECTING INFECTIOUS DISEASES
EP 01.07.2020
Int.Class C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
Appl.No 19207298 Applicant THERANOS IP COMPANY LLC Inventor PATEL PRANAV
Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.
8.WO/2020/130627DNA APTAMER SPECIFICALLY BINDING TO YELLOW FEVER VIRUS EDIII, AND USE THEREOF
WO 25.06.2020
Int.Class C12N 15/115
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
Appl.No PCT/KR2019/018001 Applicant MD HEALTHCARE INC. Inventor KIM, Yoon-Keun
The present invention relates to a DNA aptamer specifically binding to yellow fever virus envelope protein domain III (YFV EDIII), a composition for diagnosing yellow fever, containing same, a kit for diagnosing yellow fever, a biosensor for diagnosing yellow fever, and an information providing method for diagnosing yellow fever. As a result of a formal study performed by the present inventors in order to develop a novel biomarker for the diagnosis of yellow fever, it has been confirmed that a DNA aptamer having specific binding ability to YFV EDIII has strong binding force and excellent specificity with YFV EDIII. Therefore, the present invention is expected to have greater stability than an ELISA method using existing antibodies, and thus is expected to be effectively usable in the development of a composition for diagnosing yellow fever, a biosensor for diagnosing yellow fever, and an information providing method for diagnosing yellow fever and the like.
9.WO/2020/127591SYSTEM FOR CAPTURING CELLS
WO 25.06.2020
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No PCT/EP2019/086104 Applicant GREINDX AS Inventor LICHTENSTEIN, Amir
The present disclosure relates to a cell extraction device comprising: a plurality of cell extraction modules arranged in a single layer array, the single layer array having a cell-receiving side wherein an opening of at least one of the plurality of cell extraction modules on the cell- receiving surface is configured to receive and retain a single target cell from a fluid sample, and a fluid-evacuating side wherein an opening of the or each of the plurality of cell extraction modules on the fluid-evacuating side is configured to allow fluid from the fluid sample to be evacuated from the cell extraction device, wherein at least one of the plurality of cell extraction modules comprises a micropore capillary configured at a first end that is open on the cell-receiving side to receive a target cell, and configured at a second end that is open on the fluid- evacuating side to allow fluid to pass through.
10.WO/2020/130791DEVICE FOR RAPID DETECTION OF SALMONELLA BACTERIA, METHOD OF FABRICATING AND OPERATING THEREOF
WO 25.06.2020
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No PCT/MY2019/050115 Applicant UNIVERSITY OF MALAYA Inventor IBRAHIM, Fatimah
The present invention relates to a device for rapid detection of Salmonella bacteria, a method of fabricating and a method of operating thereof. The biosensor device is an aptasensor comprising a thiolated DNA aptamer, wherein the thiolated DNA aptamer is deployed onto an electrode having an active electrode area formed by a predefined photolitographic process via a carbon nanotube drop-casted thereon. The biosensor has a low detection limit of analyte and has the ability to measure a wide range of analyte concentrations.