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IC:G01N33/48

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Analysis

1.WO/2020/233147INERT CARRIER ESCHERICHIA COLI AND POTENTIAL USE THEREOF
WO 26.11.2020
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
Appl.No PCT/CN2020/071625 Applicant YANGZHOU UNIVERSITY Inventor ZHU, Guoqiang
Disclosed are an inert carrier Escherichia coli and the use thereof, wherein the inert carrier Escherichia coli has been deposited in the China General Microbiological Culture Collection Center (CGMCC), with a deposit address of Beijing, China, a deposit number of CGMCC No. 17339, a deposit date of March 18, 2019, a classification name of Escherichia coli, and a strain code of SE1. The Escherichia coli does not cause any macroscopic agglutination reaction with various chicken sera of different genetic backgrounds, i.e., does not generate a non-specific agglutination reaction with different kinds of chicken sera, has the properties of being expressed and displayed on the surface a specific antigen protein, and is used as an inert carrier in an indirect agglutination test for detecting antigens or antibodies.
2.WO/2020/235567FLUORESCENT PROBE FOR USE IN DETECTION OF BRAIN TUMOR
WO 26.11.2020
Int.Class C07K 5/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
Appl.No PCT/JP2020/019814 Applicant THE UNIVERSITY OF TOKYO Inventor KITAGAWA Yosuke
[Problem] To provide a novel fluorescent probe which can be used in a spray mode, has excellent specificity to sensitivity, also has immediacy, and enables the detection of brain tumor. [Solution] A fluorescent probe for use in the detection of brain tumor, which comprises a compound represented by formula (I) or a salt thereof: (in the formula, P1 represents an arginine residue, a histidine residue or a tyrosine residue, and P2 represents a proline residue or a glycine residue, wherein P1 is liked to an adjacent N atom to form an amide bond, and P2 is linked to P1 to form an amide bond; R1 represents 1 to 4 same or different substituents independently selected from the group consisting of a hydrogen atom and an alkyl group, a carboxyl group, an ester group, an alkoxy group, an amide group and an azide group each of which may be substituted; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group which may be substituted, or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; X represents O, Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb) or P(=O)(Ra); Ra and Rb independently represent a hydrogen atom, an alkyl group or an aryl group; and Y represents a C1-C3 alkylene group).
3.WO/2020/235607METHOD FOR DETECTING TARGET MOLECULE
WO 26.11.2020
Int.Class G01N 37/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37Details not covered by any other group of this subclass
Appl.No PCT/JP2020/019992 Applicant TOPPAN PRINTING CO., LTD. Inventor HIRASE Takumi
This method for detecting a surface target molecule and an internal target molecule of a structure comprises steps for: bringing a liquid having a structure dispersed therein into contact with a well array having a plurality of wells so as to introduce the structure into the wells; bringing an encapsulation liquid into contact with the well array so as to cause the structure to be encapsulated within each of the wells; extracting content of the structure within each of the wells; detecting at least one type of surface target molecule present on the surface of the structure within each of the wells; and detecting at least one type of internal target molecule present inside the structure within each of the wells.
4.WO/2020/235697IMPROVED METHOD FOR MANUFACTURING MICRONEEDLE-BASED DIAGNOSTIC SKIN PATCH COATED WITH APTAMER, AND PATCH
WO 26.11.2020
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No PCT/KR2019/005921 Applicant NEXMOS CO., LTD. Inventor SON, In Sik
The present invention relates to a method for manufacturing a microneedle-based diagnostic skin patch coated with an aptamer, the method comprising a step for treating the surface of a microneedle with a base to modify the surface with a carboxyl group, and binding an aptamer having an amine group. A patch according to the present invention is advantageous in that a large number of aptamers, which are much smaller in size than antibody materials, can be attached to a relatively large number of microneedle tip surfaces. In addition, since aptamers for various kinds of biomarkers can be attached at the same time, various kinds of materials can be detected simultaneously (multiplexing), and thus even a microneedle tip-based skin patch can be used as a protein chip using aptamers.
5.WO/2020/235757METHOD FOR SCREENING CANDIDATE DRUG FOR TREATING DEGENERATIVE BRAIN DISEASES
WO 26.11.2020
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No PCT/KR2019/014071 Applicant THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) Inventor KIM, Eunhee
In the present invention, it has been confirmed that FAF1 protein, which is reported to induce neuronal death, is secreted through exocytosis while being contained in exosomes, not through general protein transport pathways, thereby inducing apoptosis of other cells, and thus, through a process for selecting a test substance capable of suppressing the extracellular secretion of FAF1 protein, it is possible to screen for a therapeutic agent for degenerative brain diseases of which the major cause is neuronal death.
6.20200369782Monoclonal Antibodies, Compositions and Methods for Detecting Mucin-like Protein (MLP) as a Biomarker for Ovarian and Pancreatic Cancer
US 26.11.2020
Int.Class C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
Appl.No 16817397 Applicant University of Leicester Inventor Hans-Wilhelm Schwaeble

In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker for mucin-secreting type of cancer such as ovarian or pancreatic cancer.

7.20200370022MALIGNANT HEMATOPOIETIC CELL MICROCOMPARTMENT AND METHOD FOR PREPARING SUCH A MICROCOMPARTMENT
US 26.11.2020
Int.Class C12N 5/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09Tumour cells
Appl.No 16603264 Applicant UNIVERSITE DE BORDEAUX Inventor LAURENCE BRESSON-BEPOLDIN

The invention relates to a process for preparing cellular microcompartments comprising a hydrogel capsule surrounding a cluster of lymphomatous cells. The invention also relates to such a cellular microcompartment and the use thereof for screening anti-cancer molecules.

8.20200371062NON-ENZYMATIC ELECTROCHEMICAL SENSOR FOR MEASURING ANALYTES
US 26.11.2020
Int.Class G01N 27/416
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
Appl.No 16931279 Applicant TERUMO KABUSHIKI KAISHA Inventor Jeff T. Suri

Embodiments described herein relate generally to compositions that include a synthetic redox-active receptor, and in particular to compositions that include a boronic acid based synthetic redox-active receptor which can electrochemically sense a target analyte in a sample solution. In some embodiments, a synthetic redox-active receptor can have a composition of formula I:

embedded image

wherein the variables L, R, R′, n and X are described herein.

9.20200371092METHOD OF SCREENING ANTIBODY AND ANTIBODY SCREENING SYSTEM USING THE SAME
US 26.11.2020
Int.Class G01N 33/537
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
536with immune complex formed in liquid phase
537with separation of immune complex from unbound antigen or antibody
Appl.No 16805825 Applicant UNIVERSITY-INDUSTRY FOUNDATION(UIF), YONSEI UNIVER Inventor Jae-Chul PYUN

A method of screening an antibody comprises preparing a serum having a target antibody and a non-target antibody; providing the serum with a first antigen that specifically binds the target antibody to obtain a first mixture; selectively obtaining the first conjugate by separating the first conjugate from the non-target antibody in the first mixture; dissociating the first conjugate, and a redundant non-target antibody adsorbed to the first conjugate into the first antigen, the target antibody and the redundant non-target antibody; removing the first antigen to obtain a second mixture of the target antibody and the redundant non-target antibody; providing the second mixture with a second antigen to form a second conjugate, so that third mixture including the target antibody and the second conjugate may be obtained; and selectively obtaining a target antibody by separating the second conjugate from the target antibody in the third mixture.

10.20200371102SYSTEM AND METHOD FOR IDENTIFICATION AND CHARACTERIZATION OF TRANSGLUTAMINASE SPECIES
US 26.11.2020
Int.Class G01N 33/573
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
Appl.No 16991679 Applicant Roche Sequencing Solutions, Inc. Inventor Thomas Albert

In one aspect, the present disclosure provides a system and method for the identification and characterization of a transglutaminase. Further, the present disclosure provides transglutaminase enzymes for forming isopeptide bonds, methods of forming isopeptide bonds in the presence of transglutaminases, and substrate tags for use with transglutaminases. In another aspect, the present disclosure provides glutamine-containing substrates (or Q-tag substrates) that are more resistant to proteases/clipping and therefore, more stable, than other Q-tag substrates, and their uses in substrate tags for cross-linking to an amine-donor tag via an isopeptide bond mediated by a microbial transglutaminase.