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Analysis

1.WO/2020/181947METHOD FOR DETECTING ONE OR MORE TARGET NUCLEIC ACID SEQUENCES TO BE TESTED BY SINGLE TUBE AND KIT THEREOF
WO 17.09.2020
Int.Class C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
Appl.No PCT/CN2020/074925 Applicant JIANGSU MACRO&MICRO-TEST MED-TECH CO., LTD. Inventor LIU, Licheng
Provided are a method for detecting one or more target nucleic acid sequences to be tested by a single tube and a kit thereof. The method comprises the steps of: designing specific isothermal amplification primers and fluorescent probe RNHPs for each target nucleic acid sequence to be tested, and labeling the fluorescent probe RNHPs for each target nucleic acid sequence to be tested with different fluorescences; in the presence of a ribonuclease RNaseH, isothermally amplifying each target nucleic acid sequence to be tested under the action of a nucleic acid polymerase; and forming hybridization chain products labeled with different fluorescences by means of different target nucleic acid sequences to be tested, thereby achieving multiplex detection of a plurality of target nucleic acid sequences to be tested. In the present invention, on the basis of an isothermal amplification technique, real-time multiplex isothermal detection can be achieved just by introducing a special probe RNHP and combining same with RNaseH2.
2.WO/2020/182517CANCER DIAGNOSIS AND PROGNOSIS
WO 17.09.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/EP2020/055437 Applicant ONCOLAB DIAGNOSTICS GMBH Inventor ZEILLINGER, Robert
A method of identifying an SCLC patient at risk of disease progression comprising determining the expression of at least one marker selected from a neuroendocrine marker and/or DLLS in a blood sample or blood sample fraction of said patient, wherein said at least one marker is indicative of the patient's prognosis.
3.WO/2020/185907HERBICIDE TOLERANT PLANTS AND PRODUCTION AND DETECTION OF SAME
WO 17.09.2020
Int.Class A01H 1/04
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
1Processes for modifying genotypes
04Processes of selection
Appl.No PCT/US2020/022118 Applicant COLORADO STATE UNIVERSITY RESEARCH FOUNDATION Inventor GAINES, Todd
The present invention refers to a plant or plant part comprising a polynucleotide encoding an herbicide tolerant IAA2 polypeptide having a deleted or disrupted degron tail region, the expression of said polynucleotide confers to the plant or plant part tolerance to synthetic auxin herbicides, such as 2,4-D. The present invention relates to methods and plants and that have a deleted or disrupted degron tail region of the IAA2 protein obtained by gene editing, transformation, mutagenesis, breeding, and the like.
4.WO/2020/182106MIRNA MARKERS FOR COLORECTAL CANCER
WO 17.09.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/CN2020/078497 Applicant THE CHINESE UNIVERSITY OF HONG KONG Inventor YU, Jun
The present invention provides novel methods for diagnosing colorectal cancer in a subject or for assessing a colorectal cancer patient's likelihood of mortality from the disease by analyzing the quantity of selected miRNA species. Kits, compositions, and devices useful for these methods are also provided.
5.WO/2020/185536A NOVEL VECTOR FOR GENE TRANSFER AND GENE COPY PROLIFERATION
WO 17.09.2020
Int.Class C12Q 1/6895
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
6895for plants, fungi or algae
Appl.No PCT/US2020/021318 Applicant CLEMSON UNIVERSITY Inventor SASKI, Christopher
The invention relates to a circular vector for plant transformation comprising: a first tethering nucleic acid and a second tethering nucleic acid; a nucleic acid encoding a polynucleotide of interest (POI); a nucleic acid comprising an origin of replication; and two or more nucleic acids encoding replicon proteins and methods for using the same. Also provided are plants produced by the methods of the invention and products produced from the plant.
6.WO/2020/185846DETECTION OF DOUBLE STRANDED NUCLEIC ACIDS IN SITU AND METHODS RELATED THERETO
WO 17.09.2020
Int.Class C12Q 1/682
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
682Signal amplification
Appl.No PCT/US2020/022010 Applicant BIO-TECHNE CORPORATION Inventor MA, Xiao-Jun
The invention provides methods for detecting target double stranded nucleic acids, including for in situ hybridization assays. The invention also provides samples of fixed and permeabilized cells with a detected target double stranded nucleic acids as well as slides containing such samples. The invention additionally provides kits for detecting target double stranded nucleic acids.
7.WO/2020/185896METHODS FOR PROCESSING AND STORING DNA ENCODING FORMATS OF INFORMATION
WO 17.09.2020
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/US2020/022102 Applicant PRESIDENT AND FELLOWS OF HARVARD COLLEGE Inventor LEE, Henry Hung-yi
The present disclosure provides methods for selectively tagging a subset of polynucleotide sequences from a plurality of polynucleotides comprising (a) synthesizing a plurality of polynucleotide sequences by flexible-write synthesis on a solid support, (b) selectively releasing a subset of polynucleotide sequences from the plurality of synthesized polynucleotides, and (c) tagging the released subset of polynucleotide sequences.
8.WO/2020/185986DECREASING STAPHYLOCOCCUS AUREUS INFECTIONS IN COLONIZED PATIENTS
WO 17.09.2020
Int.Class C07K 16/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12against material from bacteria
Appl.No PCT/US2020/022226 Applicant MEDIMMUNE, LLC Inventor ESSER, Mark
The present disclosure is directed to methods of treating subjects colonized with S aureus with an anti-alpha toxin antibody or antigen-binding fragment thereof. The methods can decrease the incidence of infection attendant to the presence of S. aureus in the subject.
9.WO/2020/182175METHOD AND SYSTEM FOR MERGING ALIGNMENT AND SORTING TO OPTIMIZE
WO 17.09.2020
Int.Class G06F 16/383
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
16Information retrieval; Database structures therefor; File system structures therefor
30of unstructured textual data
38Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually
383using metadata automatically derived from the content
Appl.No PCT/CN2020/078908 Applicant HUAWEI TECHNOLOGIES CO., LTD. Inventor ROODI, Meysam
A processing unit performs alignment of a short read (SR) against a reference sequence. The reference sequence comprises a first sequence of base pairs (bps). The SR comprises a second sequence of bps. The processing unit determines whether the SR is aligned. If the SR is not aligned, the processing unit receives the next SR and processes the next SR by repeating. In response to the determination that the SR is aligned with the reference sequence at a first position in the reference sequence, the processing unit generates an SR metadata entry corresponding to the SR. The processing unit inserts the SR metadata entry to a linked list in a SR metadata collection. The position of the linked list in the SR metadata collection corresponds to the first position where the SR is aligned.
10.WO/2020/183015METHODS AND KITS FOR DETERMINING CELL SECRETED BIOMOLECULES
WO 17.09.2020
Int.Class C12Q 1/6804
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6804Nucleic acid analysis using immunogens
Appl.No PCT/EP2020/056975 Applicant EVORION BIOTECHNOLOGIES GMBH Inventor KLEINE-BRÜGGENEY, Hans
The invention inter alia pertains to methods and kits for analysis of one or more cell released biomolecules. Furthermore, the invention relates to a plurality of sequenceable products comprising different sequence elements. The described technology is useful for a variety of applications, in particular biomolecule analysis applications, e.g. for obtaining biomolecule release profiles of single cells in a multiplexed manner, wherein the cells are provided in a matrix