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Analysis

1.WO/2020/138478METHOD FOR ANALYZING AND DIAGNOSING STATES RELATED TO METASTASIS/PRIMARY ONSET OF CANCER USING RNA MODIFICATION
WO 02.07.2020
Int.Class C12Q 1/6809
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6809Methods for determination or identification of nucleic acids involving differential detection
Appl.No PCT/JP2019/051560 Applicant OSAKA UNIVERSITY Inventor KONNO Masamitsu
The present disclosure provides a new method for analyzing states related to the metastasis/primary onset of cancer in a subject. The present disclosure provides a new method for analyzing states related to the metastasis/primary onset of cancer in a subject (for example, whether a subject has metastatic cancer, and whether a cancer is primary), on the basis of the discovery that cancer metastatic states are reflected in RNA modification information. The present disclosure makes it possible to analyze various biological states including cancer metastasis, and also makes it possible to determine the cancer to be treated as well as select a suitable treatment method.
2.WO/2020/139767METHODS FOR ENHANCED DETECTION OF HEMOGLOBIN
WO 02.07.2020
Int.Class G01N 33/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
Appl.No PCT/US2019/067904 Applicant BECKMAN COULTER, INC. Inventor ZHAO, Xiaodong
Described herein are methods for quantifying hemoglobin in fluids such as urine samples. The methods employ hemoglobin control compositions containing a low strength buffer, providing lower limits of detection and increased consistency over a wider range of assay conditions.
3.WO/2020/133233PATHOGENIC MUTATION OF OSTEOGENESIS IMPERFECTA DISEASE AND DETECTION REAGENT THEREFOR
WO 02.07.2020
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No PCT/CN2018/124930 Applicant HUANG, Huan Inventor HUANG, Huan
Provided are a pathogenic mutation of osteogenesis imperfecta and a detection reagent therefor. For a mutant COL1A1 gene, single site mutation c.1822G>A (chr17:48270211) is related in the mutated COL1A1 gene, whereof the heterozygous mutation is pathogenic, the genetic mode is dominant inheritance, and for the amino acid change at p.Gly608Ser, the site mutation causes dyssynthesis of I-type collagen in connective tissue, so that a lesion is formed. Provided is a kit for detecting osteogenesis imperfecta, comprising a reagent for detecting the 1822bp-th site of a COL1A1 gene CDS or a reagent for detecting the 608-th amino acid site of a COL1A1 protein. The osteogenesis imperfecta disease can be diagnosed by detecting the pathogenic mutation (c.1822G>A on the COL1A1 gene).
4.WO/2020/134950GENE MUTATION/FUSION COMBINATION AND KIT FOR IDENTIFICATION OF BENIGN AND MALIGNANT PULMONARY NODULES
WO 02.07.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/CN2019/123432 Applicant JIANGSU MICRODIAG BIOMEDICINE TECHNOLOGY CO., LTD. Inventor WANG, Tao
Provided is a gene mutation/fusion combination using plasma as sample and using PCR technology to identify benign and malignant pulmonary nodules. The specific combination is: EGFR/KRAS or EGFR/KRAS/ALK/ROS1 or EGFR/KRAS/BRAF/ALK/ROS1 or EGFR/KRAS/BRAF/ALK/ROS1/STK11/NRAS/TP53/PIK3CA. Also provided is a relevant kit, and a layout of a detection system when the kit is used.
5.WO/2020/135689THERAPEUTIC AND PROPHYLACTIC USE OF MICROORGANISMS
WO 02.07.2020
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/CN2019/129092 Applicant THE CHINESE UNIVERSITY OF HONG KONG Inventor NG, Siew Chien
Certain microorganism species in the gut and feces of fecal microbiota transplantation (FMT) donors can affect the outcome of FMT treatment. Thus, novel methods are provided for identifying subjects as suitable donor to optimize FMT outcome and for pre-treating donors and/or receipients for optimized FMT outcome. Also provided are kits and compositions for improving FMT outcome, including for specific purposes such as for weight loss or cholesterol reduction.
6.WO/2020/135862TUMOR MARKER STAMP-EP5 BASED ON METHYLATED MODIFICATION
WO 02.07.2020
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Appl.No PCT/CN2019/129838 Applicant SHANGHAI EPIPROBE BIOTECHNOLOGY CO., LTD. Inventor LI, Zhenyan
The present invention provides a methylated tumor marker STAMP-EP5 and an application thereof, relating to the technical field of disease diagnosis markers. The present invention further provides an application of methylated tumor marker STAMP-EP5 in the preparation of tumor diagnostic reagents.
7.WO/2020/136613INSTANT READ-OUT BIOLOGICAL INDICATOR WITH GROWTH CONFIRMATION
WO 02.07.2020
Int.Class C12Q 1/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
22Testing for sterility conditions
Appl.No PCT/IB2019/061398 Applicant 3M INNOVATIVE PROPERTIES COMPANY Inventor ERICKSON, Joshua D.
A self-contained sterilization process biological indicator is provided. The indicator includes a cuvette having at least one liquid-impermeable wall that forms an opening into a compartment, a nucleic acid-interacting dye disposed in the compartment, a predetermined number of sterilization process-resistant spores disposed in the compartment, a first liquid medium disposed in the compartment, and a nutrient composition that facilitates germination and/or outgrowth of a viable spore. The spores in the self-contained sterilization process biological indicator are contacting the dye. The nutrient composition is disposed in the compartment and isolated from the spores. The opening is part of a pathway that permits passage of a sterilant gas into the compartment. The nucleic acid-interacting dye is fluorescent when it interacts with DNA or RNA. A method of using the self-contained sterilization process biological indicator to determine the effectiveness of a sterilization process is also provided.
8.WO/2020/136696METHOD FOR INDUCING MUSCULAR CELLS USING CELLS IN SPOT URINE
WO 02.07.2020
Int.Class C12N 5/07
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
Appl.No PCT/JP2018/047447 Applicant NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY Inventor TAKIZAWA Hotake
The present invention provides a non-invasive and simple method for producing myotubes, and establishes an in vitro testing system for an exon-skipping therapeutic drug for muscular dystrophy. Specifically, the present invention pertains to a method that is for producing myotubes from cells in urine, and that comprises an introduction step for introducing the MYOD1 gene into cells in urine, and an exposure step for exposing the cells in urine to at least one epigenetic control compound.
9.WO/2020/136216METHODS OF IDENTIFYING SUBJECTS HAVING OR AT RISK OF HAVING A COAGULATION RELATED DISORDER
WO 02.07.2020
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No PCT/EP2019/087038 Applicant INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Inventor TREGOUET, David-Alexandre
Coagulation factor V (FV) plays an important and dual role in the regulation of blood coagulation by exhibiting both pro- and anticoagulant functions. In order to detect novel genetic loci participating to the regulation of Factor V (FV) plasma levels, the inventors conducted the first Genome Wide Association Study on this hemostatic phenotype in a sample of 510 individuals and replicated the main findings in an independent samples of 1156 individuals. In addition to genetic variations at the F5 locus, they identified novel associations at the PLXDC2 locus with the PLXDC2 rs927826 polymorphism explaining ~3.7% (p 7.5 10 -15 in the combined discovery and replication samples) of the variability of FV plasma levels. SiRNA experiments in human hepatocellular carcinoma cell line confirmed the role of PLXDC2 in modulating factor F5 gene expression. Accordingly, detecting a genetic variant in the PLXDC2 gene would be suitable for identifying a subject having or at risk of having a coagulation related disorder.
10.WO/2020/138965METHOD FOR DIAGNOSIS OF PERIODONTAL DISEASE, AND COMPOSITION AND KIT THEREFOR
WO 02.07.2020
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No PCT/KR2019/018497 Applicant SUGENTECH, INC. Inventor KIM, Eunkyung
The present invention relates to a method for diagnosis of a periodontal disease. More particularly, a periodontal disease is diagnosed when an inflammatory disease marker including MMP-8, or a marker derived from a periodontal disease-causing strain is detected at an increased concentration, compared to a sample from a normal control. The detection of MMP-8 is separately performed for active MMP-8 and inactive MMP-8, whereby a diagnosis method and a composition and kit for diagnosis or prognosis prediction, which are of high accuracy, can be provided.