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1.WO/2020/235247ELECTROCHEMICAL DETECTION METHOD FOR PRODUCT OF CATALYZED REACTION, AND TRANSDUCER
WO 26.11.2020
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/JP2020/016079 Applicant JAPAN AVIATION ELECTRONICS INDUSTRY, LIMITED Inventor KUNIKATA, Ryota
A method for electrochemically detecting a catalyzed reaction product that is generated by a catalyzed reaction that proceeds in a first liquid mass 20 and is dissolved in the first liquid mass 20. The method involves forming the first liquid mass 20 and a second liquid mass 30 that contacts and forms a liquid-liquid interface with the first liquid mass 20 and does not dissolve the catalyzed reaction product in a liquid tank 10, arranging a working electrode 40 inside the first liquid mass 20, arranging a counter electrode 50 and a reference electrode 60 inside the second liquid mass 30, and detecting the current that flows in the working electrode 40 as a result of the catalyzed reaction product being involved in an oxidation or reduction reaction at the working electrode 40.
2.WO/2020/235567FLUORESCENT PROBE FOR USE IN DETECTION OF BRAIN TUMOR
WO 26.11.2020
Int.Class C07K 5/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
Appl.No PCT/JP2020/019814 Applicant THE UNIVERSITY OF TOKYO Inventor KITAGAWA Yosuke
[Problem] To provide a novel fluorescent probe which can be used in a spray mode, has excellent specificity to sensitivity, also has immediacy, and enables the detection of brain tumor. [Solution] A fluorescent probe for use in the detection of brain tumor, which comprises a compound represented by formula (I) or a salt thereof: (in the formula, P1 represents an arginine residue, a histidine residue or a tyrosine residue, and P2 represents a proline residue or a glycine residue, wherein P1 is liked to an adjacent N atom to form an amide bond, and P2 is linked to P1 to form an amide bond; R1 represents 1 to 4 same or different substituents independently selected from the group consisting of a hydrogen atom and an alkyl group, a carboxyl group, an ester group, an alkoxy group, an amide group and an azide group each of which may be substituted; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group which may be substituted, or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; X represents O, Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb) or P(=O)(Ra); Ra and Rb independently represent a hydrogen atom, an alkyl group or an aryl group; and Y represents a C1-C3 alkylene group).
3.WO/2020/235607METHOD FOR DETECTING TARGET MOLECULE
WO 26.11.2020
Int.Class G01N 37/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37Details not covered by any other group of this subclass
Appl.No PCT/JP2020/019992 Applicant TOPPAN PRINTING CO., LTD. Inventor HIRASE Takumi
This method for detecting a surface target molecule and an internal target molecule of a structure comprises steps for: bringing a liquid having a structure dispersed therein into contact with a well array having a plurality of wells so as to introduce the structure into the wells; bringing an encapsulation liquid into contact with the well array so as to cause the structure to be encapsulated within each of the wells; extracting content of the structure within each of the wells; detecting at least one type of surface target molecule present on the surface of the structure within each of the wells; and detecting at least one type of internal target molecule present inside the structure within each of the wells.
4.WO/2020/235767BIOMARKER FOR DIAGNOSIS OR PREDICTION OF POST-TRAUMATIC STRESS DISORDER, AND USE THEREOF
WO 26.11.2020
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No PCT/KR2020/000767 Applicant EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION Inventor LYOO, In Kyoon
The present invention relates to a biomarker for diagnosis or prediction of post-traumatic stress disorder, and a use thereof and, more particularly, to a method of providing information for diagnosis or prediction of post-traumatic stress disorder by using the biomarker.
5.WO/2020/235827METHOD FOR PROVIDING INFORMATION ABOUT THERAPEUTIC RESPONSE TO ANTICANCER IMMUNOTHERAPY, AND KIT USING SAME
WO 26.11.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/KR2020/005625 Applicant INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY Inventor KIM, Hye Ryun
The present specification provides a method for providing information about a therapeutic response to anticancer immunotherapy, and a kit for providing information by using same, the method comprising the steps of: measuring DNA methylation of pDMRs in a biological sample isolated from an individual; and evaluating the therapeutic reaction to anticancer immunotherapy for the individual on the basis of the measured DNA methylation of pDMRs.
6.20200370092METHOD AND BIOMARKERS FOR IN VITRO DIAGNOSIS OF MENTAL DISORDERS
US 26.11.2020
Int.Class C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
Appl.No 16464284 Applicant Carsten KORTH Inventor Carsten KORTH

The invention relates to a method for in vitro diagnosis of the presence of a mental disorder in a human individual or the predisposition of the human individual to the mental disorder, wherein the mental disorder is associated with a dysfunctional DISC1 protein pathway or disturbed dopamine homeostasis, the method comprising: a) measuring in a sample of a body tissue or fluid from the individual the expression levels of at least two marker genes, each of which coding for at least one marker protein; b) comparing the measured expression levels to predetermined threshold values representing the expression levels of said marker genes in a healthy population; and c) based on the comparison, determining whether the individual has the mental disorder or a predisposition to the mental disorder, wherein the measured expression levels are indicative to the mental disorder or disposition if the measured expression levels of said marker genes exceed, reach or fall below the predetermined threshold value. For example, the expression level (relative mRNA expression) of each of the marker genes Ifng, Ccl4, Il13ra1, Il12rb2, C3, and Slc27a2 is significantly decreased in a transgenic rat (TG, gray) in relation to non-transgenic littermates (LM, white). That is, the lower expression level of each tested marker gene in the transgenic rat relative to the expression level of the respective marker gene in the non-transgenic control is indicative of dysfunctional DISC1 protein pathway or disturbed dopamine homeostasis.

7.20200370122IMMUNE INDEX METHODS FOR PREDICTING BREAST CANCER OUTCOME
US 26.11.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No 15441686 Applicant Tong Zhou Inventor Tong Zhou

Provided are methods for diagnosing and predicting the outcome of a breast cancer patient or related cancers. The methods include determining expression levels of a plurality of biomarkers (selected genes) related to immune function in a biological sample, such as tumor tissues or a body fluid such as blood, from the patient. The expression levels of the biomarkers are used to derive an index which can be used as an indicator predictive of cancer patient outcome. Overexpression of a plurality of biomarkers of the invention can be used to generate a score or value which has been demonstrated herein to be indicative of a good or better patient outcome. The index, generated by the methods of the invention can also be used to stratify cancer subtypes, and also can be combined with conventional clinical parameters to better inform clinical decisions.

8.20200370132ROBUST GENOMIC PREDICTOR OF BREAST AND LUNG CANCER METASTASIS
US 26.11.2020
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No 16983235 Applicant Harry OSTRER Inventor Harry OSTRER

A method of determining the risk of metastasis of breast or lung cancer in a human subject who has or had breast or lung cancer is disclosed herein. The method is based on detecting in a sample from the subject the number of copies per cell of genes and/or genomic regions of a metastatic gene signature set disclosed herein, and determining alternations in the number of copies per cell of the genes and/or genomic regions in the signature set, as compared to the number of copies per cell in non-cancer cells, thereby determining the risk of breast/lung cancer metastasis.

9.20200371002Automated Seed Sampler And Methods Of Sampling, Testing And Bulking Seeds
US 26.11.2020
Int.Class G01N 1/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
02Devices for withdrawing samples
04in the solid state, e.g. by cutting
Appl.No 16993178 Applicant Monsanto Technology LLC Inventor Kevin L. DEPPERMANN

An automated method for sampling seeds generally includes removing material from a seed at an automated sampling station and then, after removing the material from the seed, detecting, by at least one sensor, movement of the seed out of the automated sampling station. The automated method may also include, after removing the material from the seed, transferring the seed from the automated sampling station to a seed container and transferring the material removed from the seed from the automated sampling station to a sample container.

10.20200370012METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS
US 26.11.2020
Int.Class C12N 5/0783
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
Appl.No 16759251 Applicant Novartis AG Inventor Joseph A. Fraietta

The disclosure provides methods of making CAR-expressing immune effector cells (e.g., T cells, or NK cells), and compositions and reaction mixtures comprising the same. The disclosure further provides methods of using said CAR-expressing immune effector cells.