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Analysis

1.WO/2020/138336MUTATED TRNA FOR CODON EXPANSION
WO 02.07.2020
Int.Class C40B 40/06
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
06Libraries containing nucleotides or polynucleotides, or derivatives thereof
Appl.No PCT/JP2019/051241 Applicant CHUGAI SEIYAKU KABUSHIKI KAISHA Inventor SHINOHARA, Shojiro
In some embodiments, the present disclosure relates to a mutated tRNA in which the first position of the anti-codon has been changed into lysidine or agmatidine and a translation system containing the mutated tRNA. In a specific embodiment, the present disclosure provides a mutated tRNA which is capable of selectively translating codon NNA. In another embodiment, the present disclosure provides a translation system which is capable of translating two or three kinds of amino acids from one codon box. In still another embodiment, the present disclosure provides a novel synthesis method for lysidine diphosphate, agmatidine diphosphate and derivatives thereof.
2.WO/2020/138543ORNITHINE DECARBOXYLASE MUTANT STRAIN AND APPLICATION THEREOF
WO 02.07.2020
Int.Class C12N 9/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
Appl.No PCT/KR2018/016764 Applicant CJ CHEILJEDANG CORPORATION Inventor KIM, Byung-Gee
The present invention relates to a generation method for an ornithine decarboxylase mutant strain, characteristics of the mutant strain, a gene encoding the ornithine decarboxylase mutant strain, and a method for producing putrescine using the generation method, the characteristics, and the gene. The present invention has effects of increasing productivity or production efficiency of putrescine and reducing costs in the purification of putrescine by suppressing a side reaction.
3.WO/2020/138919ORNITHINE DECARBOXYLASE VARIANT AND METHOD FOR PRODUCING PUTRESCINE BY USING SAME
WO 02.07.2020
Int.Class C12N 9/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
Appl.No PCT/KR2019/018404 Applicant CJ CHEILJEDANG CORPORATION Inventor LEE, Jaehun
The present application relates to: an ornithine decarboxylase or a protein variant thereof; a polynucleotide encoding same; a microorganism containing same; and a method for producing putrescine by using same. The present invention achieves effects of increasing the productivity, production efficiency or production selectivity of putrescine, and reducing costs during putrescine purification by suppressing side reactions.
4.WO/2020/135747OPTIMIZED IN VITRO CELL-FREE PROTEIN SYNTHESIS SYSTEM AND APPLICATION THEREOF
WO 02.07.2020
Int.Class C12N 15/63
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Appl.No PCT/CN2019/129289 Applicant KANGMA-HEATHCODE (SHANGHAI) BIOTECH CO., LTD. Inventor GUO, Min
Disclosed is an optimized in vitro cell-free protein synthesis system and an application thereof, comprising: a cell extract, being a yeast cell extract with an inserted T7 RNA polymerase gene; a carbohydrate, being a mixture of glucose and maltodextrin; a phosphate compound; a buffering agent, being a trishydroxymethylaminomethane buffering agent; and a DNA molecule template encoding a heterologous protein prepared by using a nucleic acid isothermal amplification method. In the DNA molecule template, a sequence shown in SEQ ID NO. 1 is inserted upstream of the coding sequence of the heterologous protein. By means of optimization, the cost of in vitro protein synthesis is reduced, and the yield of target protein is increased.
5.WO/2020/136236A DEVICE AND METHOD FOR CONVERTING AND SEPARATING AT LEAST ONE REACTANT AND A REACTION PRODUCT THEREOF
WO 02.07.2020
Int.Class B01D 11/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
11Solvent extraction
04of solutions which are liquid
Appl.No PCT/EP2019/087071 Applicant VITO NV Inventor MATASSA, Claudia
The invention relates to a method and a device device for converting at least one reactant(5) into a reaction product and separating the at least one reactant from the reaction product, wherein the device comprises a vessel (10) with a vessel inner volume (11) and a confinement (20) submerged in the vessel inner volume (11), the confinement (20) providing a confinement inner (21) volume which is in fluid connection with the vessel inner volume (11), wherein the vessel inner volume (11) contains a first fluid (1) with a first density ρ1 and a second fluid with a second density ρ2, with ρ1 > ρ2, so that the first fluid (1) forms a lower phase and the second fluid (2) forms an upper phase in the vessel inner volume (11), wherein the confinement contains a third fluid (3) with a third density ρ3 with ρ3 > ρ2 so that the second fluid forms an upper layer and the third fluid forms a lower layer in the confinement inner volume (21), wherein the third fluid may be the same as or different from and is physically separated from the first fluid (1), wherein at least one of the first, second fluid and third fluid is at most partly with the other two, but preferably immiscible, wherein the at least one reactant (5) and the reaction product (6) have a different affinity for at least two of the first, second (2) and third fluid, wherein at least one of the first (1) and third fluid (3) contain a fourth phase (4) which is a solid or semi solid and is selected from the group of materials capable of promoting the conversion of the at least one reactant into the reaction product.
6.WO/2020/137017WHITENING AGENT, HYALURONIC ACID PRODUCTION PROMOTER, COLLAGEN PRODUCTION PROMOTER, INTRACELLULAR ACTIVE OXYGEN SCAVENGER, IRRITATION MITIGATOR, WRINKLE-AMELIORATING AGENT, COMPLEX, COSMETIC AND EXTERNAL PREPARATION FOR SKIN
WO 02.07.2020
Int.Class A61K 8/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
60Sugars; Derivatives thereof
Appl.No PCT/JP2019/035511 Applicant NIPPON FINE CHEMICAL CO., LTD. Inventor KOTERA, Hiroki
The present invention provides new uses of phosphatidylinositol. Further, the present invention provides a composition capable of easily and stably dispersing phosphatidylinositol in water and a technique whereby phosphatidylinositol can be easily and stably dispersed in water. Phosphatidylinositol (PI), in particular, a PI-rich composition produced by a specific method can be used as a whitening agent, a hyaluronic acid production promoter, a collagen production promoter, an intracellular active oxygen scavenger, an irritation mitigator and a wrinkle-ameliorating agent. The problem of the present invention can be solved by: a complex obtained by, from a solution in which component (A1) which is phosphatidylinositol, component (A2) which is lecithin and component (A3) which is a sterol are homogeneously dissolved in an organic solvent, removing the organic solvent and thus simultaneously precipitating components (A1) to (A3); and a cosmetic or an external preparation for skin which contains, as essential components, component (A) which is a composition comprising phosphatidylinositol and lecithin, component (B) which is a polyhydric alcohol and component (C) which is water.
7.WO/2020/136237WEISSELLA VIRIDESCENS STRAIN AND USES THEREOF FOR THE SYNTHESIS OF EXOPOLYSACCHARIDES
WO 02.07.2020
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
Appl.No PCT/EP2019/087073 Applicant SANT DALMAI, S.A.U. Inventor PANELLA GUBAU,, Josep
The present invention relates to a strain of the species Weissella viridescens with accession number CECT 9735 that displays a significantly increased ability to synthesize exopolysaccharides (EPS) compared to other strains of the same genus in the prior art. Specifically, the strain of the invention described herein comprises a polynucleotide sequence encoding an enzyme responsible for the synthesis of said EPS, wherein said sequence is comprised in a mobile element and not in the cell genome. Furthermore, this invention relates to the EPS, per se, secreted by said cell, as well as the said EPS production method.
8.WO/2020/138449FERMENTED COMPOSITION OF COFFEE CHERRY FLESH AND PERICARP EXTRACT AND METHOD FOR PRODUCING SAME
WO 02.07.2020
Int.Class C12P 7/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
24containing a carbonyl group
26Ketones
Appl.No PCT/JP2019/051500 Applicant KIRIN HOLDINGS KABUSHIKI KAISHA Inventor TSUJI Sayaka
The present invention provides a fermented composition of coffee cherry flesh and pericarp extract that has an increased β–damascenone content, and a method for producing same. More specifically, the method for producing the fermented composition of coffee cherry flesh and pericarp extract includes a fermenting step employing lactobacillus.
9.WO/2020/138489NOVEL ANTI-CCR8 ANTIBODY
WO 02.07.2020
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No PCT/JP2019/051603 Applicant SHIONOGI & CO., LTD. Inventor KODAMA Mai
Disclosed is a novel anti-CCR8 antibody. The antibody may be used for treating or preventing cancers or the like.
10.WO/2020/138815E. COLI VARIANT STRAIN OR CORYNEBACTERIUM GLUTAMICUM VARIANT STRAIN PRODUCING L-AMINO ACIDS, AND METHOD FOR PRODUCING L-AMINO ACIDS USING SAME
WO 02.07.2020
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
Appl.No PCT/KR2019/017934 Applicant DAESANG CORPORATION Inventor LEE, Sun Hee
The present invention pertains to: an L-amino acid-producing E. coli variant strain or Corynebacterium glutamicum variant strain having an enhanced ability to produce L-amino acids; and a method for producing L-amino acids using same. The L-amino acid-producing E. coli variant strain or Corynebacterium glutamicum variant strain according to the present invention exhibits an enhanced ability to produce L-amino acids, such as L-tryptophan, L-phenylalanine, L-tyrosine, L-glutamine, L-lysine, L-arginine, L-valine, L-leucine, L-isoleucine, L-threonine, L-histidine, L-serine, and L-citrulline, compared to parental strains, and can produce highly concentrated L-amino acids at high yield.