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Analysis

1.WO/2020/229249MODIFIED S2 SUBUNIT OF THE CORONAVIRUS SPIKE PROTEIN
WO 19.11.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/EP2020/062528 Applicant BOEHRINGER INGELHEIM VETMEDICA GMBH Inventor KRAEMER-KUEHL, Annika
The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 865. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
2.111793651用于COVID-19药物筛选的慢病毒表达载体及其构建方法
CN 20.10.2020
Int.Class C12N 15/867
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
867Retroviral vectors
Appl.No 202010700324.1 Applicant 广东源心再生医学有限公司 Inventor 林彬
本发明公开了一种用于COVID‑19药物筛选的慢病毒表达载体的构建方法,其是以pCW‑Cas9‑Blast为骨架载体,将nCoVN cDNA亚克隆到所述骨架载体中,构成新型冠状病毒核衣壳蛋白的慢病毒表达载体pCW‑Puro‑T2A‑nCoVN;其中,所述nCoVN cDNA带有一个6×his标签和嘌呤霉素抗性基因。本发明所构建的用于COVID‑19药物筛选的慢病毒表达载体对实验环境要求低,常规实验室即可操作,可高通量操作,仅需2天即可构建载体并大量获得。
3.111778264基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎疫苗
CN 16.10.2020
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No 202010675912.4 Applicant 广州佰芮慷生物科技有限公司 Inventor 罗升学
本发明公开了一种基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎COVID‑19疫苗。通过优化外源基因使得外源蛋白的表达能够明显提高,同时进一步尝试使用人稀有或者猴的腺病毒作为载体,逃避预存的针对常见腺病毒的免疫反应,本发明获得的新型冠状病毒肺炎COVID‑19疫苗能够在动物体内诱导产生高水平的体液和细胞免疫,在动物免疫之后没有发现副作用的出现。本发明新型冠状病毒肺炎COVID‑19疫苗是安全有效且可以进行快速大量的制备,因此是可用于预防SARS‑CoV‑2的感染的候选疫苗株。
4.111778271一种表达SARS-CoV-2 N蛋白的重组质粒、重组菌及构建方法和应用
CN 16.10.2020
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
Appl.No 202010706688.0 Applicant 梁建国 Inventor 梁建国
本发明提供了一种表达SARS‑CoV‑2 N蛋白的重组质粒、重组菌及构建方法和应用,属于疫苗技术领域,所述重组质粒以pET‑N‑GST‑Thrombin‑C‑His为骨架质粒,插入有编码SARS‑CoV‑2 N蛋白的基因的全长序列。本发明采用pET‑N‑GST‑Thrombin‑C‑His表达载体表达SARS‑CoV‑2 N蛋白(新冠病毒核蛋白),SARS‑CoV‑2 N蛋白的表达量高,且表达得到的SARS‑CoV‑2 N蛋白能够保持良好的蛋白活性,进而能够应用于多个免疫学检测平台,来辅助监控新冠病毒的感染和爆发。
5.111732638一种针对SARS-CoV-2的疫苗
CN 02.10.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010632922.X Applicant 重庆博唯佰泰生物制药有限公司 Inventor 傅文彬
本发明提供一种针对SARS‑CoV‑2的疫苗。本发明采用改造后的SARS‑CoV‑2的S蛋白,尤其是氨基酸序列如SEQ ID NO:2、如SEQ ID NO:3或者SEQ ID NO:4所示蛋白质用于制备疫苗制剂,具有较好的免疫原性,为治疗SARS‑CoV‑2引起的疾病提供了新的方案。
6.111718951重组新型冠状病毒COVID-19 S蛋白、其制备方法及应用
CN 29.09.2020
Int.Class C12N 15/81
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
80for fungi
81for yeasts
Appl.No 202010594498.4 Applicant 宁波毓昌生物技术有限公司 Inventor 刘海昌
本发明公开了一种重组新型冠状病毒COVID‑19S蛋白、其制备方法及应用。该制备方法包括:将经过密码子优化的编码COVID‑19S蛋白的核苷酸序列构建入酵母细胞诱导表达载体中,然后转入酵母细胞进行培养后诱导表达,并进行纯化,从而获得重组COVID‑19S蛋白。本发明制备方法设计巧妙,可以获得具有免疫学活性的高纯度的重组COVID‑19S蛋白,该蛋白可以作为一个主要的诊断试剂成分,用于诊断COVID‑19感染病人的IgM和IgG,还有可能成为COVID‑19病毒的亚单位疫苗,用于预防COVID‑19病毒的流行。另外采用以甲醇毕赤酵母为代表酵母蛋白表达,具有表达量高,可诱导,糖基化机制接近高等真核生物,分泌蛋白易纯化,易实现高密发酵等优点,可应用于大规模工业化发酵生产。
7.111705006表达新型冠状病毒S蛋白的口服重组酵母及其制备与应用
CN 25.09.2020
Int.Class C12N 1/19
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
16Yeasts; Culture media therefor
19modified by introduction of foreign genetic material
Appl.No 202010529961.7 Applicant 天津大学 Inventor 黄金海
本发明公开了一种表达新型冠状病毒S蛋白的口服重组酵母及其制备与应用,其包含S蛋白的16位至1035位氨基酸,优选RBD结构域和FP融合肽。将体外构建的S蛋白截断体完整转录单位GPD‑S(RBD‑FP)‑TU,通过同源重组整合于酵母基因组,利用Aga1‑Aga2表面展示系统将S蛋白展示于酵母细胞表面,获得S蛋白表面展示型的重组酵母菌株ST1814G‑S(RBD‑FP),并利用所得菌株制备口服重组酵母。本发明的口服重组酵母成本低廉、生产使用安全、操作简便、安全有效,具有免疫保护作用,为COVID‑19的防控提供选择。
8.111690042识别2019-nCOV抗体的NP蛋白及检测工具
CN 22.09.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010355800.0 Applicant 苏州大学 Inventor 徐兴顺
本发明涉及生物检测领域,特别涉及识别2019‑nCOV抗体的NP蛋白及检测工具。本发明提供的胶体金检测试剂盒,包括能够识别2019‑nCOV抗体的NP蛋白,具有特异性好、灵敏度高、准确度高、方便快捷、易于操作、经济实惠的特点。
9.111690621一种含有IRES-S1-N基因的重组病毒及其制备方法和应用
CN 22.09.2020
Int.Class C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
Appl.No 202010628618.8 Applicant 西南大学 Inventor 胡海霞
本发明公开了一种含有IRES‑S1‑N基因的重组病毒及其制备方法和应用。该重组病毒包括插入有IRES和S1‑N基因的新城疫病毒弱毒株LaSota基因组;其核苷酸序列如SEQ ID NO.1所示。本发明利用新城疫病毒LaSota株作为载体,能有效表达两种外源蛋白,增强免疫保护效果,同时,该重组疫苗可以在鸡胚内或细胞内大批量繁殖,经济实用,安全高效。
10.111690043基于SARS-CoV-2核蛋白的NTD多肽、编码基因、重组载体、表达方法及应用
CN 22.09.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010443211.8 Applicant 秦小波 Inventor 秦小波
本发明属于生物医药技术领域,涉及基于SARS‑CoV‑2核蛋白的NTD多肽、编码基因、重组载体、表达方法及应用;制备方法为:1)人工合成NTD多肽蛋白序列对应的核苷酸序列为模板,并克隆到大肠杆菌表达载体上,构建得到重组质粒;2)将所得的重组质粒转化大肠杆菌感受态细胞,挑选阳性克隆,获得重组大肠杆菌表达菌株;3)以获得的重组大肠杆菌表达菌株为发酵菌株进行液体发酵,发酵过程中,在添加异丙基硫代半乳糖IPTG后,产生NTD多肽,并利用组氨酸标签通过亲和层析纯化得到NTD多肽;本发明制备的NTD多肽方便高效,发酵工艺简单、耗时短、成本低,目的蛋白表达量达菌体总蛋白的20%以上。