Processing

Please wait...

Settings

Settings

Goto Application

Offices all Languages en Stemming true Single Family Member true

Save query

A private query is only visible to you when you are logged-in and can not be used in RSS feeds

Query Tree

Refine Options

Offices
All
Specify the language of your search keywords
Stemming reduces inflected words to their stem or root form.
For example the words fishing, fished,fish, and fisher are reduced to the root word,fish,
so a search for fisher returns all the different variations
Returns only one member of a family of patents

Full Query

IC:C07K14/165

Side-by-side view shortcuts

General
Go to Search input
CTRL + SHIFT +
Go to Results (selected record)
CTRL + SHIFT +
Go to Detail (selected tab)
CTRL + SHIFT +
Go to Next page
CTRL +
Go to Previous page
CTRL +
Results (First, do 'Go to Results')
Go to Next record / image
/
Go to Previous record / image
/
Scroll Up
Page Up
Scroll Down
Page Down
Scroll to Top
CTRL + Home
Scroll to Bottom
CTRL + End
Detail (First, do 'Go to Detail')
Go to Next tab
Go to Previous tab

Analysis

1.WO/2020/229249MODIFIED S2 SUBUNIT OF THE CORONAVIRUS SPIKE PROTEIN
WO 19.11.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/EP2020/062528 Applicant BOEHRINGER INGELHEIM VETMEDICA GMBH Inventor KRAEMER-KUEHL, Annika
The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 865. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
2.202020105116Reagenzien und Verwendungen zur Diagnose einer SARS-CoV-2-Infektion
DE 12.11.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202020105116 Applicant Charité - Universitätsmedizin Berlin Inventor

Verwendung eines Polypeptides umfassend SEQ ID NO1 oder eine Variante davon, die an einen Antikörper gegen SED ID NO1 aus einer Probe von einem Patienten binden kann, zur Herstellung eines diagnostischen Kits. embedded image

3.10822379Molecules that bind to SARS-CoV-2
US 03.11.2020
Int.Class A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
Appl.No 15931939 Applicant University of Pittsburgh—Of the Commonwealth System of Higher Education Inventor Dimiter Stanchev Dimitrov

This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, and/or antibody domain) to a SARS-CoV-2 antigen. For example, binders (e.g., antibodies, antigen binding fragments, and antibody domains) that bind to a SARS-CoV-2 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having COVID-19 (or a viral infection caused by SARS-CoV-2) are provided.

4.111825750ACE2受体保护性合成短肽在新型冠状病毒感染的应用
CN 27.10.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010432965.3 Applicant 谭骏 Inventor 谭骏
ACE2受体保护性合成短肽在新型冠状病毒感染的应用,涉及人医药技术领域,本发明公开了血管紧张素转化酶II(ACE2)受体保护短肽的氨基酸顺序及其赖氨基酸和C‑16脂肪酸修饰后在预防和治疗新型冠状病毒(SARS‑CoV‑2)感染的应用,同时,从分子、细胞及动物水平检测了这些融合的短肽能高效和特异性靶向阻断SARS‑CoV‑2‑S蛋白RBD与ACE2受体相互作用,最终,以鼻内给药方式予ACE2保护性短肽阻止了病毒侵入靶细胞,1、C6KRBD‑GZ5:[C‑16]KKKKKKYLYRLF;2、C6KRBD‑GZ26:KKKKKKYK[C‑16]YRYLRHGKLR;3、C6KRBD‑GZ28:KKKKKK[C‑16]VEGFVEGFNCYFPLQS。
5.2788393Coronavirus de bovino atenuado y vacunas relacionadas
ES 21.10.2020
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 15756662 Applicant Intervet International B.V. Inventor PETERS, Catherine M
6.2788459Método y reactivos para el diagnóstico de SARS-CoV-2
ES 21.10.2020
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No 20158626 Applicant Euroimmun Medizinische Labordiagnostika AG Inventor
7.111781352新型冠状病毒N-His重组蛋白芯片平台的构建方法
CN 16.10.2020
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No 202010731489.5 Applicant 广东医科大学附属医院 Inventor 吴东
本发明提供了一种新型冠状病毒N‑His重组蛋白芯片平台的构建方法,通过pET28a N质粒先制备有良好抗原性的N重组蛋白,然后再利用该N重组蛋白去确定第一抗体和第二抗体的最佳稀释度,最后用构建的芯片检测梯度稀释的血清确定好芯片的检测限和线性范围,由此去完成N基因重组蛋白芯片平台的构建。相对于RT‑PCR检测方法,本芯片具有更稳定的检测性能,还具有高通量、微型化等特点,不易受病毒变异的影响,可以更精准、快速的实现对2019‑nCoV大批量的筛查。
8.111778264基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎疫苗
CN 16.10.2020
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No 202010675912.4 Applicant 广州佰芮慷生物科技有限公司 Inventor 罗升学
本发明公开了一种基于新型腺病毒载体Sad23L和/或Ad49L的新型冠状病毒肺炎COVID‑19疫苗。通过优化外源基因使得外源蛋白的表达能够明显提高,同时进一步尝试使用人稀有或者猴的腺病毒作为载体,逃避预存的针对常见腺病毒的免疫反应,本发明获得的新型冠状病毒肺炎COVID‑19疫苗能够在动物体内诱导产生高水平的体液和细胞免疫,在动物免疫之后没有发现副作用的出现。本发明新型冠状病毒肺炎COVID‑19疫苗是安全有效且可以进行快速大量的制备,因此是可用于预防SARS‑CoV‑2的感染的候选疫苗株。
9.111778271一种表达SARS-CoV-2 N蛋白的重组质粒、重组菌及构建方法和应用
CN 16.10.2020
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
Appl.No 202010706688.0 Applicant 梁建国 Inventor 梁建国
本发明提供了一种表达SARS‑CoV‑2 N蛋白的重组质粒、重组菌及构建方法和应用,属于疫苗技术领域,所述重组质粒以pET‑N‑GST‑Thrombin‑C‑His为骨架质粒,插入有编码SARS‑CoV‑2 N蛋白的基因的全长序列。本发明采用pET‑N‑GST‑Thrombin‑C‑His表达载体表达SARS‑CoV‑2 N蛋白(新冠病毒核蛋白),SARS‑CoV‑2 N蛋白的表达量高,且表达得到的SARS‑CoV‑2 N蛋白能够保持良好的蛋白活性,进而能够应用于多个免疫学检测平台,来辅助监控新冠病毒的感染和爆发。
10.111766389一种基于鸡传染性支气管炎病毒重组N蛋白的ELISA抗体检测试剂盒
CN 13.10.2020
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No 202010736902.7 Applicant 郑州大学 Inventor 周景明
本发明公开了一种基于鸡传染性支气管炎病毒重组N蛋白的ELISA抗体检测试剂盒,包括用于包被酶标板的IBV H120毒株重组N蛋白。该IBV H120毒株重组N蛋白通过原核表达系统E.coli Transetta(DE3)表达,首先构建原核克隆载体pMD19‑T‑N,然后再构建原核表达载体pGEX‑6P‑1‑N及诱导表达和纯化:设计引物RT‑PCR扩增IBV H120 N基因,然后将N基因与pMD‑19‑T进行连接,构建得到原核克隆载体pMD19‑T‑N;以pMD19‑T‑N为模板,PCR扩增N基因,将N基因与pGEX‑6p‑1连接,构建得到原核表达载体pGEX‑6P‑1‑N。本试剂盒具有成本低廉、使用简单方便、敏感性高且特异性强的优点,可以批量检测,为IBV抗体水平监测提供了一种可靠的检测手段。