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1.WO/2020/182227PREPARATION METHOD FOR HIGH PURITY LIRAGLUTIDE SIDE CHAIN
WO 17.09.2020
Int.Class C07D 207/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
46with hetero atoms directly attached to the ring nitrogen atom
Appl.No PCT/CN2020/088481 Applicant AMPHASTAR NANJING PHARMACEUTICALS,INC. Inventor CHENG, Lihua
Disclosed is a preparation method for high purity liraglutide side chain, comprising: using palmitic acid, N-hydroxysuccinimide and N,N’-diisopropylcarbodiimide as reaction starting materials, and sequentially obtaining Palmitoyl-OSu, Palmitoyl-Glu-OtBu and liraglutide side chain crude product Palmitoyl-Glu(OSu)-OtBu; filtering the reaction solution, washing the resulting filtrate with an acidic aqueous solution, and concentrating the organic phase until dry; recrystallizing the organic phase with an alkane, a fatty alcohol or a mixed solvent thereof to obtain high purity liraglutide side chain. The preparation method for high purity liraglutide side chain has a simple operation, a short synthesis cycle, low costs and easy post-processing, the product purity can reach up to 99.41%, and HOSU, DIU, myristic acid, L5-S2 and stearic acid impurities, as well as other unknown impurities, can be effectively removed, which is beneficial for mass production.
2.WO/2020/182577PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
WO 17.09.2020
Int.Class C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No PCT/EP2020/055724 Applicant SYNGENTA CROP PROTECTION AG Inventor KOLLETH KRIEGER, Amandine
Compounds of the formula (I) wherein the substituents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling animal pests, including arthropods and in particular insects, nematodes, molluscs or representatives of the order Acarina.
3.WO/2020/182587STERICALLY HINDERED AMINE STABILIZER MIXTURES
WO 17.09.2020
Int.Class C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Appl.No PCT/EP2020/055754 Applicant BASF SE Inventor VITALI, Manuele
The present invention relates to mixtures of sterically hindered amines of the formulae (1 ) and (2) wherein at least one of the radicals Z1, Z2, Z3, Z4, Z5 and Z6 is C1-C18 alkyloxy or C5-C7 cycloalkyloxy and the remaining of the radicals Z1, Z2, Z3, Z4, Z5 and Z6 are hydrogen, hydroxy, C1-C18 alkyloxy or C5-C7 cycloalkyloxy, and at least one of the radicals Y1, Y2, Y3, Y4, Y5 and Y6 is a group of formula -CH2-CH=CH-R and the remaining of the radicals Y1, Y2, Y3, Y4, Y5 and Y6 are hydrogen or a group of formula -CH2-CH=CH-R, and the other substituents are as defined according to the present invention, methods for stabilization of an organic material, and a process for the preparation of compounds of formula (1').
4.WO/2020/183307DIHYDRO-SPIRO[INDOLINE-3:1'-ISOQUINOLIN]-2-ONES AND THEIR ANALOGUES AND DERIVATIVES AND METHODS OF TREATING CANCER AND OTHER DISEASES
WO 17.09.2020
Int.Class C07D 471/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Appl.No PCT/IB2020/051930 Applicant THE UNIVERSITY OF BUEA Inventor MABANYI, Lobe Maloba Mesembe
The present invention is directed to various 3',4'-dihydro-2'H-spiro[indoline-3:1'-isoquinolin]-2-one compounds and methods for treating disease states and/or conditions which are mediated through sphingosine-1-phosphate receptor(s). The present invention is also directed to the use of these compounds as anticancer agents and as modulators of sphingosine-1-phosphate receptor function in the treatment of disease states and/or conditions which are mediated through these receptors. In addition, the invention relates to pharmaceutical compositions comprising one or more of these compounds alone or in combination with other therapeutic agents. The invention is also directed to methods of treatment of cancer and/or conditions that may respond to the modulation of sphingosine-1-phospate receptor function and which employ compounds of the present invention or pharmaceutical compositions comprising one or more of the compounds of this invention.
5.WO/2020/186027INHIBITORS OF CGAS FOR TREATING AUTOINFLAMMATORY DISEASES AND CANCER METASTASIS
WO 17.09.2020
Int.Class A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Appl.No PCT/US2020/022334 Applicant TOMITA, Daisuke Inventor TOMITA, Daisuke
Tri-cyclyl nitrogen-containing heterocyclic compounds are disclosed. The compounds are inhibitors of human cGAS in interferon-producing cell types. They are thus useful as therapeutic agents for treating cGAS-related autoimmune diseases in humans.
6.WO/2020/186077MOLECULARLY IMPRINTED POLYMERS FOR EXTRACTION OF CANNABINOIDS AND USES THEREOF
WO 17.09.2020
Int.Class C07D 311/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
Appl.No PCT/US2020/022427 Applicant 6TH WAVE INNOVATIONS CORP. Inventor KALIVRETENOS, Aristotle
The present disclosure relates to molecularly imprinted polymers that target cannabinoid(s), including THC and CBD, as well as methods of making molecularly imprinted polymers that target cannabinoid(s), including THC and CBD and uses thereof.
7.WO/2020/181386FLUORINATED BENZO[F]BENZIMIDAZOL-4-9-DIONE IUM DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE AS SURVIVIN SUPPRESSANTS
WO 17.09.2020
Int.Class C07D 235/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
Appl.No PCT/CA2020/050336 Applicant TRILLIUM THERAPEUTICS INC. Inventor SLASSI, Abdelmalik
The present application relates to novel fluorinated derivatives, to processes for their preparation, to compositions comprising them, and to their use in therapy. More specifically, it relates to compounds useful in the treatment of diseases, disorders or conditions mediated by survivin inhibition. In particular, the present application includes compounds of Formula (I) or (II), and compositions and uses thereof: (Formulae (I) (II)).
8.WO/2020/181646METHOD FOR PREPARING TRIAZOLE COMPOUNDS
WO 17.09.2020
Int.Class C07D 249/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Appl.No PCT/CN2019/086613 Applicant PURPANA (BEIJING) TECHNOLOGIES CO., LTD Inventor JIAO, Ti
Disclosed is a method for preparing triazole compounds. The synthetic route is as follows: performing a substitution reaction of a compound represented by formula III as a main raw material and a compound represented by formula IV under alkaline conditions to synthesize triazole compounds represented by formula V. The method has the following advantages: simple operation, low cost, high yield, pollution-free, safe and environmentally friendly, and is suitable for modern industrial production.
9.WO/2020/182666SMALL MOLECULE MODULATORS OF IL-17
WO 17.09.2020
Int.Class C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Appl.No PCT/EP2020/056038 Applicant LEO PHARMA A/S Inventor LIANG, Xifu
The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
10.WO/2020/184906ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME
WO 17.09.2020
Int.Class C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
Appl.No PCT/KR2020/003141 Applicant DOOSAN SOLUS CO., LTD. Inventor SIM, Jaeyi
The present invention relates to a novel organic light emitting compound and an organic electroluminescent device using same and, more particularly, to a compound having excellent thermal stability, electrochemical stability, light-emitting ability, and hole/electron transport ability, and an organic electroluminescent device including the compound in one or more organic material layers so as to have improved properties of light-emitting efficiency, driving voltage, lifespan and the like.