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Analysis

1.WO/2020/232597DIAMINE COMPOUND, PREPARATION METHOD THEREFOR, THERMOSETTING RESIN COMPOSITION, AND APPLICATION
WO 26.11.2020
Int.Class C07C 229/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
52having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
Appl.No PCT/CN2019/087608 Applicant SHENGYI TECHNOLOGY CO., LTD. Inventor LIN, Wei
The present invention provides a diamine compound, a preparation method therefor, and a thermosetting resin composition. The diamine compound has a structure as represented by structural formula (I). The structure of the diamine compound has both an aromatic amine group and an aryl ester-based functional group. As a curing agent for epoxy resin, the thermosetting resin composition of the diamine compound is low in dielectric constant and dielectric loss factor, has good thermal resistance and toughness, and has excellent bond strength to metals.
2.WO/2020/232807NAPHTHOQUINONE FUSED TRIAZOLE DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF
WO 26.11.2020
Int.Class C07D 249/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
16condensed with carbocyclic rings or ring systems
22Naphthotriazoles
Appl.No PCT/CN2019/095288 Applicant GUANGZHOU UNIVERSITY OF CHINESE MEDICINE (GUANGZHOU ACADEMY OF CHINESE MEDICINE) Inventor LIU, Jiawei
Provided are a naphthoquinone fused triazole derivative, preparation method and application thereof. The naphthoquinone fused triazole derivative has a structure represented by the following formula (I), wherein X is C or N; R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8 are each independently any one of hydrogen, halogen, hydroxyl, cyano, sulfydryl, amino, nitro, nitroso, alkyl, alkoxy, ester group, carboxyl and sulfonyl. Also provided is the application of the naphthoquinone fused triazole derivative or a pharmaceutically acceptable salt or hydrate thereof in preparation of a medicament for treating a disease with abnormal signal transduction of STAT3.
3.WO/2020/233677PROCESS FOR PREPARING AMIDE-SUBSTITUTED IMIDAZO COMPOUNDS
WO 26.11.2020
Int.Class C07D 235/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
Appl.No PCT/CN2020/091603 Applicant BEIGENE (BEIJING) CO., LTD. Inventor WANG, Hexiang
Disclosed herein is a process for preparing amide-substituted imidazo compounds. In particular, disclosed herein is the process for preparing certain amide-substituted imidazo compounds that are useful for inhibiting indoleamine 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.
4.WO/2020/235567FLUORESCENT PROBE FOR USE IN DETECTION OF BRAIN TUMOR
WO 26.11.2020
Int.Class C07K 5/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
Appl.No PCT/JP2020/019814 Applicant THE UNIVERSITY OF TOKYO Inventor KITAGAWA Yosuke
[Problem] To provide a novel fluorescent probe which can be used in a spray mode, has excellent specificity to sensitivity, also has immediacy, and enables the detection of brain tumor. [Solution] A fluorescent probe for use in the detection of brain tumor, which comprises a compound represented by formula (I) or a salt thereof: (in the formula, P1 represents an arginine residue, a histidine residue or a tyrosine residue, and P2 represents a proline residue or a glycine residue, wherein P1 is liked to an adjacent N atom to form an amide bond, and P2 is linked to P1 to form an amide bond; R1 represents 1 to 4 same or different substituents independently selected from the group consisting of a hydrogen atom and an alkyl group, a carboxyl group, an ester group, an alkoxy group, an amide group and an azide group each of which may be substituted; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group which may be substituted, or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; X represents O, Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb) or P(=O)(Ra); Ra and Rb independently represent a hydrogen atom, an alkyl group or an aryl group; and Y represents a C1-C3 alkylene group).
5.WO/2020/235587TANDOSPIRONE DERIVATIVE
WO 26.11.2020
Int.Class C07D 209/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
56Ring systems containing three or more rings
58- or -condensed
724,7-Endo-alkylene-iso-indoles
76with oxygen atoms in positions 1 and 3
Appl.No PCT/JP2020/019911 Applicant NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF TOYAMA Inventor KONDO Takashi
A compound represented by formula (1) or a pharmaceutically acceptable salt thereof can be used as an active ingredient of a drug for central nervous system diseases or as a candidate compound for a precursor of said active ingredient. In formula (1), R1, R2, and R3 each independently represent a substance selected from the group consisting of a hydrogen atom, a hydroxy group, and an alkoxy group having 1-6 carbon atoms, and at least one of R1, R2, and R3 is a hydroxy group.
6.WO/2020/235947CACB1-DERIVED PEPTIDE, VARIANT OF CACB1-DERIVED PEPTIDE, AND USE THEREOF
WO 26.11.2020
Int.Class A61K 38/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
Appl.No PCT/KR2020/006650 Applicant KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION Inventor YOUN, Dong-ho
The present invention relates to a Cacb1-derived peptide, a variant of the Cacb1-derived peptide, a composition for the prevention or treatment of hypertension, and a composition for the relaxation of blood vessels, the compositions comprising same. The Cacb1-derived peptide and the variant of the Cacb1-derived peptide according to the present invention have an excellent blood pressure-lowering effect and fewer side effects, and are easy to manufacture and industrialize, and thus can be effectively used in the development of a novel therapeutic agent for hypertension. In addition, the peptide and the variant thereof have a potential vasodilating effect, and thus are expected to be used as candidate materials for a therapeutic agent for diseases that can be treated or ameliorated by vasodilation, such as angina, prostatic hyperplasia, and erectile dysfunction.
7.20200368162Nucleic Acid-Based Therapy of Muscular Dystrophies
US 26.11.2020
Int.Class A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
Appl.No 16487734 Applicant ModernaTX, Inc. Inventor Paolo Martini

The invention related to polynucleotides comprising an open reading frame of linked nucleosides encoding therapeutic proteins or variant therapeutic proteins, isoforms thereof, functional fragments thereof, and fusion proteins comprising therapeutic proteins. In some embodiments, the open reading frame is sequence-optimized. The invention also relates to methods of treating muscular dystrophies.

8.20200368282METHODS FOR EXPANSION OR DEPLETION OF T-REGULATORY CELLS
US 26.11.2020
Int.Class A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Appl.No 16986755 Applicant The General Hospital Corporation Inventor Denise L. FAUSTMAN

The invention features methods of producing compositions enriched in Tregs and methods for treating immunological disorders using these compositions. The invention also features methods for producing compositions enriched in lymphocytes and depleted of Tregs and the use of these compositions in the treatment of proliferative disorders.

9.20200368372NIR-CONJUGATED TUMOR-SPECIFIC ANTIBODIES AND USES THEREOF
US 26.11.2020
Int.Class A61K 49/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
Appl.No 16993950 Applicant CITY OF HOPE Inventor Paul YAZAKI

Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.

10.20200369682FUSED THIOPHENE DERIVATIVES AND THEIR USES
US 26.11.2020
Int.Class C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No 16967751 Applicant ENYO PHARMA Inventor ERIC MELDRUM

The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.