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IC:A61K39/215

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1.20200368346LIQUID VACCINES OF LIVE ENVELOPED VIRUSES
US 26.11.2020
Int.Class A61K 39/155
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
155Paramyxoviridae, e.g. parainfluenza virus
Appl.No 16769820 Applicant Intervet Inc. Inventor Paul Vermeij

The present invention describes a liquid vaccine composition of a live enveloped virus and a pharmaceutically acceptable carrier, whereby the carrier is a natural deep-eutectic solvent (NADES), and the vaccine has a water activity of less than about 0.8. The NADES provides a stabilisation of the sensitive virus for prolonged time and at ambient temperature. In general, the liquid vaccine compositions according to the invention, in different compositions for the various enveloped viruses, show remarkable capabilities of stabilisation. This overcomes the need for lyophilisation, a great economic benefit. Also the liquid nature of the vaccines facilitates administration to human or animal targets.

2.3741846HUMAN BETACORONAVIRUS LINEAGE C AND IDENTIFICATION OF N-TERMINAL DIPEPTIDYL PEPTIDASE AS ITS VIRUS RECEPTOR
EP 25.11.2020
Int.Class C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Appl.No 20151448 Applicant UNIV ERASMUS MED CT ROTTERDAM Inventor HAAGMANS BARTHOLOMEUS LEONARDUS
The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.
3.WO/2020/229249MODIFIED S2 SUBUNIT OF THE CORONAVIRUS SPIKE PROTEIN
WO 19.11.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/EP2020/062528 Applicant BOEHRINGER INGELHEIM VETMEDICA GMBH Inventor KRAEMER-KUEHL, Annika
The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 865. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
4.20200354410MODIFIED S1 SUBUNIT OF THE CORONAVIRUS SPIKE PROTEIN
US 12.11.2020
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Appl.No 16867650 Applicant Boehringer Ingelheim Vetmedica GmbH Inventor Annika KRAEMER-KUEHL

The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.

5.111875680一种预防新型冠状病毒微颗粒的制备方法及应用
CN 03.11.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010792018.5 Applicant 武汉圣润生物科技有限公司 Inventor 黄浩
本发明提供一种预防新型冠状病毒微颗粒制备方法及应用,涉及疫苗领域。具体地,所述制备方法包括以下步骤:1)构建过表达刺突(S)蛋白的重组质粒;2)将重组质粒包装成慢病毒颗粒;3)用慢病毒颗粒对成纤维细胞进行感染,得到表达S蛋白的工具性细胞;4)将得到的工具性细胞及培养液进行X线照射,收集放疗后的上清液,获得所需微颗粒和凋亡的工具性细胞碎片混合物;5)将得到的混合物进行离心、浓缩、纯化后,即得疫苗。本发明利用了放疗诱导工具细胞释放的微颗粒作为载体,可在过表达新型冠状病毒S蛋白的情况下,直接激活机体抗病毒免疫,产生抗新型冠状病毒的中和抗体。本发明可诱导机体产生高水平中和抗体免疫反应,同时具备良好的生物安全性。
6.111870691获得浓缩IgY免疫球蛋白调配物的乳化疫苗、其方法及用途
CN 03.11.2020
Int.Class A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
Appl.No 202010817218.1 Applicant 研究应用股份公司 Inventor E·卢西奥德卡尼尼
本申请涉及获得浓缩IgY免疫球蛋白调配物的乳化疫苗、其方法及用途。本发明涉及基于投与高度浓缩的禽类来源的免疫球蛋白调配物来治疗或预防动物的若干疾病的一种疗法,所述禽类来源的免疫球蛋白调配物是从预先用包含感染物或毒素抗原、轻质矿物油及粒状佐剂的疫苗调配物超免疫的母鸡的蛋黄获得。
7.111848753新型冠状病毒抗原表位及其应用
CN 30.10.2020
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010699909.6 Applicant 中国科学院过程工程研究所 Inventor 刘瑞田
本发明提供了新型冠状病毒抗原表位及其应用。利用超级计算机模拟新型冠状病毒S、E、M、N蛋白结构,计算获得新型冠状病毒抗原表位SEQ ID NO:1~38。这些表位具有很好的免疫原性;部分表位多肽诱导产生的抗体具有中和新型冠状病毒的作用;抗原表位能够与国内外新型冠状病毒病人血清中的抗体结合,具有抗多种新型冠状病毒毒株的潜力,同时也具有对不同毒株进行鉴别应用的潜力。本发明所提供的抗原表位可用于:①新型冠状病毒疫苗及MERS病毒、SARS病毒等冠状病毒通用疫苗的研发;②新型冠状病毒抗体制备,并进一步用于病毒检测、分型及病毒所致疾病的治疗。本发明在预防冠状病毒及其传播和爆发以及病毒毒株检测诊断方面具有广阔的应用前景。
8.111840543猪流行性腹泻病毒弱毒疫苗粘膜免疫增强剂及制备工艺和应用
CN 30.10.2020
Int.Class A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
Appl.No 202011013413.5 Applicant 兆丰华生物科技(南京)有限公司 Inventor 张渊魁
本发明涉及动物疫苗技术领域,尤其是一种猪流行性腹泻病毒弱毒疫苗粘膜免疫增强剂及制备工艺和应用,所述免疫增强剂为三价融合型蛋白质,由产肠毒素性大肠杆菌耐热肠毒素的STⅠ型、STⅡ型以及霍乱弧菌ST毒素组成,其基因核酸序列如SEQ ID No:1所示。该三价融合蛋白与佐剂乳化制备免疫原疫苗免疫动物,能刺激机体产生高滴度的抗体,免疫原性良好,克服了单个ST分子免疫原性差的弱点和不足。三价融合蛋白与猪流行性腹泻病毒弱毒疫苗株联合使用,能够显著增强猪流行性腹泻病毒特异性sIgA抗体水平、延长其抗体持续期、降低哺乳仔猪的腹泻率和死亡率,是一种理想的猪流行性腹泻病毒弱毒疫苗佐剂。
9.111840536非侵入性经鼻腔接种的冠状病毒疫苗及制备方法
CN 30.10.2020
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202010845977.9 Applicant 北京福原科技有限公司 Inventor 郁小兵
本发明公开了一种非侵入性经鼻腔接种的冠状病毒疫苗及制备方法,在冠状病毒疫苗中的添加相当于冠状病毒疫苗量0.01‑10%的助剂;所述助剂至少包括4℃呈液态37℃呈固态的温敏性给药材料。本发明优点:①保护疫苗,防止抗原被酶消化;②能够延长和促进呼吸道粘膜的M细胞和普通上皮细胞摄取抗原的时间;③减少疫苗的刺激和毒副作用,达到高效低毒。
10.111840532预防病毒性传染病的活疫苗
CN 30.10.2020
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No 202010767025.X Applicant 陈继明 Inventor 陈继明
本发明属于生物医药技术领域。它公布了一类预防病毒性传染病的活疫苗。所述活疫苗含有活病毒,并且所述活疫苗中的活病毒是与单克隆抗体结合的,借助单克隆抗体的中和作用抑制疫苗中活病毒的致病性。随着单克隆抗体技术的快速发展,以活病毒与中和性单克隆抗体形成的免疫复合物为基础制备的活疫苗,具有疫苗种毒制备快速、不担心疫苗病毒致病能力返强、安全性高、免疫保护作用好、适合于多种病毒性传染病的预防、无需制备大量的含有中和性抗体的人或动物血清等优点。