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Analysis

1.WO/2020/138026HEAT STRESS ALLEVIATION AGENT
WO 02.07.2020
Int.Class A23C 9/13
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
CDAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
9Milk preparations; Milk powder or milk powder preparations
12Fermented milk preparations; Treatment using microorganisms or enzymes
13using additives
Appl.No PCT/JP2019/050488 Applicant HAYASHIBARA CO., LTD. Inventor HASHIMOTO Satoko
The present invention addresses the problem of providing a novel heat stress alleviation agent that can be taken simply, safely, and easily, even by infants and the elderly, who are susceptible to heat stress such as heatstroke, that rapidly promotes sweating in heat stress environments, and that prevents, alleviates, or improves symptoms and disorders caused by heat stress, such as heatstroke. Provided are: a heat stress alleviation agent that contains glycosyl hesperidin as an active ingredient; and a basal body temperature maintenance agent that contains glycosyl hesperidin as an active ingredient.
2.WO/2020/138407MEDICINAL PRODUCT
WO 02.07.2020
Int.Class A61K 31/423
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
Appl.No PCT/JP2019/051390 Applicant KOWA COMPANY, LTD. Inventor NISHIDA, Chisa
Provided is a technique for suppressing the change in blending between pemafibrate or a salt of pemafibrate or a solvate of pemafibrate or the salt and a (meth)acrylic acid-based polymer. A medicinal product comprising: an air-tight packaging material; and a pharmaceutical composition which is included in the air-tight packaging material and comprises (A) pemafibrate or a salt of pemafibrate or a solvate of pemafibrate or the salt and (B) a (meth)acrylic acid-based polymer.
3.WO/2020/138428THERAPEUTIC AGENT FOR INHERITED BRADYARRHYTHMIA
WO 02.07.2020
Int.Class A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
Appl.No PCT/JP2019/051456 Applicant OSAKA UNIVERSITY Inventor ASANO, Yoshihiro
[Problem] To provide a therapeutic agent for inherited bradyarrhythmia. [Solution] A therapeutic agent for bradyarrhythmia, which contains a compound (I) or (II) or a pharmacologically acceptable salt thereof as an active ingredient. (In the formula, Ph represents a phenyl group.)
4.WO/2020/139209STABLE INJECTABLE POSACONAZOLE FORMULATIONS COMPRISING CYCLODEXTRIN AND SUGAR
WO 02.07.2020
Int.Class A61K 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
Appl.No PCT/TR2018/050922 Applicant POLIFARMA ILAC SANAYI VE TICARET ANONIM SRKETI Inventor KUMRULU, Vildan
The present invention relates to stable injectable formulations comprising the active ingredient posaconazole and cyclodextrin and sugar as excipients and the use of such formulations in the treatment of invasive infections caused by Candida, Aspergillus type fungi.
5.WO/2020/139571DOMPERIDONE COMPOSITIONS AND METHODS FOR TREATING DEPRESSION
WO 02.07.2020
Int.Class A61K 31/381
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
Appl.No PCT/US2019/065973 Applicant CHASE THERAPEUTICS CORPORATION Inventor CHASE, Thomas, N.
The present invention describes the combination of domperidone with pramipexole or a pharmaceutically acceptable salt or solvate thereof, useful for treating depressive disorders, including major depressive disorder.
6.WO/2020/139999PANCREATIC CANCER TREATMENT
WO 02.07.2020
Int.Class A01N 33/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
33Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
02Amines; Quaternary ammonium compounds
Appl.No PCT/US2019/068665 Applicant KUMAR, Addanki Pratap Inventor KUMAR, Addanki Pratap
Methods and composition of treatment of pancreatic cancer are disclosed. Certain embodiments are directed to methods for treating pancreatic cancer comprising administering an effective amount of a composition comprising palmatine or palmatine derivatives to a patient that has cancer. In certain embodiments a chemotherapy agents is administered in combination with palmatine. Certain embodiments are directed to an anti-pancreatic cancer composition comprising palmatine and a chemotherapy agent.
7.WO/2020/135123METHOD FOR PREPARING ALBUMIN NANOPARTICLES BASED ON FREE RADICAL OXIDATION
WO 02.07.2020
Int.Class A61K 9/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
Appl.No PCT/CN2019/125591 Applicant HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY Inventor WANG, Jiangling
The present invention relates to the field of pharmaceutical preparations, and specifically discloses a method for preparing albumin nanoparticles based on free radical oxidation, comprising the following steps: preparing albumin aqueous solution with an albumin concentration of 1-20 mg/mL; (2) whilst stirring, adding free radical generating agent to the albumin aqueous solution, and continuing to stir and react for 1-60 min at 15-50 ℃; the free radicals generated by the free radical generating agent are used for oxidising the albumin, and the oxidised albumin molecules assemble to form albumin nanoparticles that are mainly bonded by hydrophobic action, thereby obtaining an albumin nanoparticle solution. The present invention implements improvement by means of the key reaction mechanism of the nano particle preparation method and the corresponding design of the finishing process and, compared to the prior art, can effectively solve the problems of the complexity, high cost, and high toxicity of preparing nanoparticles; the present invention has simple processes and low production costs, and is suitable for large-scale industrial production.
8.WO/2020/135352METHOD FOR PREPARING PROGESTERONE PARTICULATE, PREPARED PROGESTERONE PARTICULATE AND INJECTION THEREOF
WO 02.07.2020
Int.Class A61K 31/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
Appl.No PCT/CN2019/127555 Applicant SICHUAN KELUN PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. Inventor LIANG, Xiangyong
Disclosed is a method for preparing a progesterone particulate, especially a crystal or powder. The method comprises: step 1, dissolving progesterone in a solvent to provide a progesterone solution; step 2, pumping the progesterone solution into a high-speed shearing progesterone precipitation solvent at a predetermined speed to precipitate progesterone; and step 3, separating the precipitate and freeze-drying same to obtain the progesterone particulate, wherein the progesterone particulate being a progesterone crystal or progesterone powder. By using the method of the present invention, a micron-sized progesterone crystal or powder having good stability can be obtained. The progesterone injection prepared by using same not only achieves a sustained release effect of at least 5 days, but also has good stability. The method of the present invention is simple to operate, has low cost, and is easily scaled up for industrial production.
9.WO/2020/135483THIENOPYRIDINONE COMPOUNDS
WO 02.07.2020
Int.Class C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No PCT/CN2019/128224 Applicant JANSSEN PHARMACEUTICA NV Inventor QIN, Luoheng
New thienopyridinone compounds, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds as FGFR (fibroblast growth factor receptor) inhibitors and their use in the treatment of diseases e.g.cancer are provided
10.WO/2020/135765CXCR4 INHIBITOR AND APPLICATION THEREOF
WO 02.07.2020
Int.Class C07D 213/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
36Radicals substituted by singly-bound nitrogen atoms
Appl.No PCT/CN2019/129362 Applicant ZHUHAI NOBEL INSTITUTE OF BIOMEDICINE CO., LTD. Inventor HUANG, Ziwei
The present invention relates to a compound and use of the compound in drug preparation, a pharmaceutical composition containing the compound, a drug carrier, and drug combined use. The compound is a compound represented by formula (I), or a stereisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof.