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1. WO2021007066 - PROCESS FOR REMOVING HG2+ FROM BODILY FLUIDS

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[ EN ]

WE CLAIM AS OUR INVENTION:

1. A process for removing Hg2+ toxins from bodily fluids selected from the group consisting of blood, gastrointestinal fluids and dialysate solution comprising contacting the fluid containing the toxins with an ion exchanger at ion exchange conditions thereby removing the Hg2+ from the fluid, the ion exchanger selected from the group consisting of a titanium metallates, the metallates respectively having an empirical formula on an anhydrous basis of:

AmTlNbaSlxOy

where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, rubidium ion, cesium ion, calcium ion, magnesium ion, hydronium ion or mixtures thereof,“m” is the mole ratio of A to Ti and has a value from 0.10 to 3,“a” is the mole ratio of Nb to Ti and has a value from zero to 0.60, "x" is the mole ratio of Si to Ti has a value from 0 to 3, and "y" has a value from 2.05 to 11 and wherein said titanium metallate has a topology selected from the group consisting of sodium nonatitanate, sitinakite, acid treated zorite and mixtures thereof.

2. The process of claim 1 wherein the bodily fluid is selected from the group consisting of whole blood, blood plasma, or other component of blood, gastrointestinal fluids and dialysate solution containing blood, blood plasma, other component of blood or

gastrointestinal fluids.

3. The process of claim 1 where x = 0, a > 0, and the ion exchanger is a titanium niobium

oxide with the sodium nonatitanate topology.

4. The process of claim 1 where A is sodium, calcium, magnesium, hydronium ion or mixtures thereof.

5. The process of claim 1 wherein the ion exchanger is packed into hollow fibers incorporated into a membrane.

6. The process of claim 1 wherein said process is a hemoperfusion process wherein said bodily fluid is sent through a column containing said ion exchanger.

7. The process of claim 1 wherein a dialysate solution is introduced into a peritoneal cavity and then is flowed through at least one adsorbent bed containing at least one of said ion exchanger.

8. The process of claim 1 wherein said process is continuous ambulatory peritoneal dialysis or automated peritoneal dialysis.

9. A composition comprising a combination of a bodily fluid, a dialysate solution or a mixture of said bodily fluid and said dialysate solution said combination further comprising an ion exchanger selected from the group consisting of a titanium metallates, the metallates respectively having an empirical formula on an anhydrous basis of:

AmTlNbaSlxOy

where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, rubidium ion, cesium ion, calcium ion, magnesium ion, hydronium ion or mixtures thereof,“m” is the mole ratio of A to Ti and has a value from 0.10 to 3,“a” is the mole ratio of Nb to Ti and has a value from zero to 0.60, "x" is the mole ratio of Si to Ti has a value from 0 to 3, and "y" has a value from 2.05 to 11 and wherein said titanium metallate has a topology selected from the group consisting of sodium nonatitanate, sitinakite, acid treated zorite and mixtures thereof.

10. An apparatus comprising a matrix containing a support material for an ion exchanger selected from the group consisting of a titanium metallates, the metallates respectively having an empirical formula on an anhydrous basis of:

AmTlNbaSlxOy

where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, rubidium ion, cesium ion, calcium ion, magnesium ion, hydronium ion or mixtures thereof,“m” is the mole ratio of A to Ti and has a value from 0.10 to 3,“a” is the mole ratio of Nb to Ti and has a value from zero to 0.60, "x" is the mole ratio of Si to Ti has a value from O to 3, and "y" has a value from 2.05 to 11 and wherein said titanium metallate has a topology selected from the group consisting of sodium nonatitanate, sitinakite, acid treated zorite and mixtures thereof.