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1. WO2021005374 - DIAGNOSTIC REAGENT

Publication Number WO/2021/005374
Publication Date 14.01.2021
International Application No. PCT/GB2020/051654
International Filing Date 09.07.2020
IPC
A61K 39/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
04Mycobacterium, e.g. Mycobacterium tuberculosis
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Applicants
  • THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS [GB]/[GB]
Inventors
  • JONES, Gareth
  • MIDDLETON, Sonya
  • STEINBACH, Sabine
  • VORDERMEIER, Hans Martin
Agents
  • TURNER, Rhiannon
Priority Data
1909953.011.07.2019GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIAGNOSTIC REAGENT
(FR) RÉACTIF DE DIAGNOSTIC
Abstract
(EN)
The invention provides a Mycobacterium Tuberculosis Complex (MTC) (for example, M. bovis and/or M. tuberculosis) diagnostic reagent comprising the reagent components: a. a Rv3616c antigen polypeptide and/or a Rv3616c antigenic cocktail;5 b. a Rv1789 antigen polypeptide and/or a Rv1789 antigenic cocktail; c. a Rv3810 antigen polypeptide and/or a Rv3810 antigenic cocktail; and d. a Rv3478 antigen polypeptide and/or a Rv3478 antigenic cocktail. The diagnostic reagent may further comprise one or more of a ESAT-6 antigen polypeptide and/or a ESAT-6 antigenic cocktail; a CFP-10 antigen polypeptide and/or a CFP-10 antigenic 10 cocktail; a Rv3615c antigen polypeptide and/or a Rv3615c antigenic cocktail; and/or SEQ ID NO:207 (a fusion protein of ESAT-6 and CFP-10 and Rv3615c). There are also provided methods and kits involving use of the diagnostic reagent.
(FR)
L'invention concerne un réactif de diagnostic de Complexe Mycobacterium Tuberculosis (MTC) (par exemple, M. bovis et/ou M. tuberculosis) comprenant les composants réactifs suivants : a. un polypeptide antigénique Rv3616c et/ou un cocktail antigénique Rv3616c; 5 b. un polypeptide antigénique Rv1789 et/ou un cocktail antigénique Rv1789; c. un polypeptide antigénique Rv3810 et/ou un cocktail antigénique Rv3810; et d. un polypeptide antigénique Rv3478 et/ou un cocktail antigénique Rv3478. Le réactif de diagnostic peut en outre comprendre un ou plusieurs éléments parmi un polypeptide antigénique ESAT-6 et/ou un cocktail antigénique ESAT-6; un polypeptide antigénique CFP-10 et/ou un cocktail antigénique CFP-10; un polypeptide antigénique Rv3615c et/ou un cocktail antigénique Rv3615c; et/ou la SEQ ID NO:207 (une protéine de fusion de ESAT-6 et CFP-10 et Rv3615c). L'invention concerne également des méthodes et des kits impliquant l'utilisation du réactif de diagnostic.
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