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1. WO2020235967 - COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING AUTOIMMUNE DISEASES

Publication Number WO/2020/235967
Publication Date 26.11.2020
International Application No. PCT/KR2020/006714
International Filing Date 22.05.2020
IPC
A61K 31/569 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
568substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstane, testosterone
569substituted in position 17 alpha, e.g. ethisterone
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A23L 33/10 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A61K 8/63 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
63Steroids; Derivatives thereof
A61Q 19/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
CPC
A23L 33/10
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A61K 31/569
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
568substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
569substituted in position 17 alpha, e.g. ethisterone
A61K 8/63
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
63Steroids; Derivatives thereof
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
A61Q 90/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
90Cosmetics or similar toilet preparations for specific uses not provided for in other groups of this subclass
Applicants
  • 연세대학교 산학협력단 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY [KR]/[KR]
Inventors
  • 이은직 LEE, Eun Jig
  • 윤진숙 YOON, Jin Sook
  • 김진주 KIM, Jin Joo
Agents
  • 이재영 LEE, Jae Young
Priority Data
10-2019-006074823.05.2019KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING AUTOIMMUNE DISEASES
(FR) COMPOSITION DE PRÉVENTION, DE SOULAGEMENT OU DE TRAITEMENT DE MALADIES AUTO-IMMUNES
(KO) 자가면역질환의 예방, 개선 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a composition for preventing, alleviating or treating autoimmune diseases. The composition of the present invention not only suppresses the expression level of transcription factor proteins involved in induction of differentiation of orbital fibroblasts, but also significantly reduces the expression level of inflammatory cytokines, thereby very effectively inhibiting the differentiation of orbital fibroblasts. Thus, the composition of the present invention can be very effectively applied to the prevention, alleviation or treatment of autoimmune diseases, for example, Graves' orbitopathy.
(FR)
La présente invention concerne une composition de prévention, de soulagement ou de traitement de maladies auto-immunes. La composition de la présente invention supprime non seulement le niveau d’expression des protéines facteurs de transcription impliquées dans l’induction de la différenciation des fibroblastes orbitaux, mais également réduit significativement le niveau d’expression des cytokines inflammatoires, inhibant ainsi très efficacement la différenciation des fibroblastes orbitaux. Ainsi, la composition de la présente invention peut être très efficacement appliquée à la prévention, au soulagement ou au traitement des maladies auto-immunes, par exemple, à l’orbitopathie de Graves.
(KO)
본 발명은 자가면역질환의 예방, 개선 또는 치료용 조성물에 관한 것으로서, 본 발명의 조성물은 안와 섬유모세포의 분화 유도와 관련된 전사인자 단백질의 발현 수준을 억제할 뿐만 아니라, 염증성 사이토카인의 발현 수준을 현저하게 감소시킴으로써, 안와 섬유모세포의 분화를 매우 효과적으로 억제할 수 있다. 이를 통해 본 발명의 상기 조성물은 자가면역질환, 예를 들면 그레이브스 안병증의 예방, 개선 또는 치료에 매우 효과적으로 적용될 수 있다.
Also published as
Latest bibliographic data on file with the International Bureau