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1. WO2020235727 - COMPOSITION FOR SKIN WHITENING COMPRISING FRACTION OF INULA HELENIUM EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT

Publication Number WO/2020/235727
Publication Date 26.11.2020
International Application No. PCT/KR2019/006211
International Filing Date 23.05.2019
IPC
A61K 8/9789 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
96containing materials, or derivatives thereof, of undetermined constitution
97from algae, fungi, lichens or plants; from derivatives thereof
9783Angiosperms
9789Magnoliopsida
A61K 8/49 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61Q 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
02for chemically bleaching or whitening the skin
A61K 36/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A61K 31/343 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
CPC
A23L 33/105
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
105Plant extracts, their artificial duplicates or their derivatives
A61K 31/343
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 36/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A61K 8/49
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 8/9789
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
96containing materials, or derivatives thereof of undetermined constitution
97from algae, fungi, lichens or plants; from derivatives thereof
9783Angiosperms [Magnoliophyta]
9789Magnoliopsida [dicotyledons]
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
Applicants
  • 서울대학교 산학협력단 SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION [KR]/[KR]
Inventors
  • 김영식 KIM, Yeong Shik
  • 강삼식 KANG, Sam Sik
  • 고혜진 KO, Hyejin
  • 송광호 SONG, Kwangho
Agents
  • 이원희 LEE, Won Hee
Priority Data
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR SKIN WHITENING COMPRISING FRACTION OF INULA HELENIUM EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT
(FR) COMPOSITION POUR LE BLANCHIMENT DE LA PEAU COMPRENANT UNE FRACTION D'EXTRAIT D'INULA HELENIUM OU UN COMPOSÉ ISOLÉ DE CELUI-CI EN TANT QUE PRINCIPE ACTIF
(KO) 토목향 추출물의 분획물 또는 이로부터 분리한 화합물을 유효성분으로 포함하는 피부 미백용 조성물
Abstract
(EN)
The present invention relates to a cosmetic composition for skin whitening comprising a hexane fraction of an Inula helenium extract, or an alantolactone or isoalantolactone compound isolated therefrom as an active ingredient. The fraction or compound according to the present invention inhibits melanin synthesis, and the compound of the present invention exhibits an effect of inhibiting mRNA or protein expression of a microphthalmia-associated transcription factor (MITF) which is a melanin synthesis promoting factor, tyrosinase, tyrosinase related protein 1, or tyrosinase related protein 2, and thus can be effectively used as a cosmetic composition for skin whitening, a pharmaceutical composition, or a functional health food.
(FR)
La présente invention concerne une composition cosmétique pour le blanchiment de la peau comprenant une fraction hexane d'un extrait d'Inula helenium, ou un composé d'alantolactone ou d'isoalantolactone isolé de celui-ci en tant que principe actif. La fraction ou le composé selon la présente invention inhibe la synthèse de la mélanine, et le composé de la présente invention présente un effet d'inhibition de l'expression de l'ARNm ou protéique d'un facteur de transcription associé à la microphtalmie (MITF) qui est un facteur favorisant la synthèse de la mélanine, de la tyrosinase, de la protéine 1 liée à la tyrosinase, ou de la protéine 2 liée à la tyrosinase, et peut ainsi être efficacement utilisé en tant que composition cosmétique pour le blanchiment de la peau, en tant que composition pharmaceutique ou qu'aliment santé fonctionnel.
(KO)
본 발명은 토목향(Inula helenium) 추출물의 헥산 분획물, 또는 이로부터 분리된 알란토락톤 또는 이소알란토락톤 화합물을 유효성분으로 포함하는 피부 미백용 화장료 조성물에 관한 것으로, 본 발명에 따른 분획물 또는 화합물은 멜라닌 합성을 억제하고, 본 발명의 화합물은 멜라닌 합성 촉진 인자인 MITF(microphthalmia-associated transcription factor), 타이로시나제(tyrosinase), 타이로시나제 관련 단백질 1(tyrosinase related protein 1) 또는 타이로시나제 관련 단백질 2(tyrosinase related protein 2)의 mRNA 또는 단백질 발현을 억제하는 효과를 나타내므로, 피부 미백용 화장료 조성물, 약학적 조성물 또는 건강기능식품으로 유용하게 사용될 수 있다.
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