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1. WO2020183456 - CANNABINOID COMBINATIONS FOR TREATING CHRONIC PAIN IN DIALYSIS PATIENTS

Publication Number WO/2020/183456
Publication Date 17.09.2020
International Application No. PCT/IL2020/050271
International Filing Date 09.03.2020
IPC
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 47/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
A61K 36/185 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 13/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 25/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
CPC
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
A61K 47/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
Applicants
  • BOL PHARMA LTD. [IL]/[IL]
Inventors
  • GEDO, Tamir
Agents
  • STRICHMAN-ALMASHANU, Liora
  • STRICHMAN-ALMASHANU, Liora
Priority Data
62/816,18510.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CANNABINOID COMBINATIONS FOR TREATING CHRONIC PAIN IN DIALYSIS PATIENTS
(FR) COMBINAISONS DE CANNABINOÏDES POUR LE TRAITEMENT DE LA DOULEUR CHRONIQUE CHEZ DES PATIENTS SOUS DIALYSE
Abstract
(EN)
The present invention is directed to a cannabinoid combination comprising, as the only cannabinoids, cannabidiol (CBD) and A9-tetrahydrocannabinol (THC), or enantiomers, diastereomers, or racemates thereof, for use in the treatment of chronic pain and associated symptoms in a subject suffering from end-stage renal disease (ESRD) and treated with dialysis, or for improving the efficacy and/or reducing adverse effects of at least one analgesic used for treating pain in a subject suffering from ESRD and treated with dialysis, wherein the CBD:THC weight ratio in the cannabinoid combination is about of 4:1 to about 10:1, preferably about 6:1.
(FR)
La présente invention concerne une combinaison de cannabinoïdes comprenant, en tant que seuls cannabinoïdes, du cannabidiol (CBD) et de l'A9-tétrahydrocannabinol (THC) ou des énantiomères, des diastéréomères ou des racémates correspondants, destinée à être utilisée dans le traitement de la douleur chronique et de symptômes associés chez un sujet souffrant d'une insuffisance rénale terminale (IRT) et traité par dialyse ou à améliorer l'efficacité et/ou à réduire les effets secondaires d'au moins un analgésique utilisé pour traiter la douleur chez un sujet souffrant d'IRT et traité par dialyse, le rapport pondéral CBD:THC dans la combinaison de cannabinoïdes étant d'environ 4:1 à environ 10:1, de préférence d'environ 6:1.
Latest bibliographic data on file with the International Bureau