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1. WO2020181140 - CONSTRAINED CONDITIONALLY ACTIVATED BINDING PROTEINS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2020/021270 1184595009WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
05 March 2020 05 March 2019
Applicant
MAVERICK THERAPEUTICS, INC.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
This International Searching Authority found multiple inventions in this international application, as follows:
1. claims: 1-18
Activatable fusion proteins binding to CD3 and to the tumor antigens B7H3, EpCAM, Trop2 or CA9
2. claim: 19
Single domain antigen binding domain binding to Trop2
3. claim: 20
Single domain antigen binding domain binding to B7H3
4. claim: 21
Single domain antigen binding domain binding to CA9
5. claim: 22
Single domain antigen binding domain binding to EpCAM
1.
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable claims.
2.
As all searchable claims could be searched without effort justifying additional fees, this Authority did not invite payment of additional fees.
3.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers only those claims for which fees were paid, specifically claims Nos.:
4.
No required additional search fees were timely paid by the applicant. Consequently, this international search report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-18
Remark on Protest
The additional search fees were accompanied by the applicant’s protest and, where applicable, the payment of a protest fee.
The additional search fees were accompanied by the applicant’s protest but the applicable protest fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61P 35/00 (2006.01)i; C07K 16/28 (2006.01)i; C07K 16/30 (2006.01)i; C07K 16/18 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61P; C07K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, Sequence Search

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
WO 2018160754 A2 (HARPOON THERAPEUTICS INC [US]) 07 September 2018 (2018-09-07)
1-18
figure 2
(2)
A
WO 2017156178 A1 (MAVERICK THERAPEUTICS INC [US]) 14 September 2017 (2017-09-14)
1-18
cited in the application
figure 3
figure 4
(3)
A
WO 2017087789 A1 (REVITOPE LTD [GB]; COBBOLD MARK [US]) 26 May 2017 (2017-05-26)
1-18
figure 1
(4)
A
US 2010003253 A1 (LAEREMANS TOON [BE] ET AL) 07 January 2010 (2010-01-07)
1-18
example 5
(5)
X,P
WO 2019051102 A2 (MAVERICK THERAPEUTICS INC [US]) 14 March 2019 (2019-03-14)
1-18
the whole document
(6)
X,P
WO 2020033837 A1 (MAVERICK THERAPEUTICS INC [US]) 13 February 2020 (2020-02-13)
1-18
the whole document
(7)
X,P
WO 2019051122 A2 (MAVERICK THERAPEUTICS INC [US]; DUBRIDGE ROBERT B [US] ET AL.) 14 March 2019 (2019-03-14)
1-18
cited in the application
the whole document
(8)
X,P
WO 2019222283 A1 (HARPOON THERAPEUTICS INC [US]) 21 November 2019 (2019-11-21)
1-18
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2018160754 A2
07 September 2018
EP 3589662 A2
US 2020148771 A1
WO 2018160754 A2
08 January 2020
14 May 2020
07 September 2018
WO 2017156178 A1
14 September 2017
AU 2017229687 A1
BR 112018068189 A2
CA 3016165 A1
CN 109071667 A
EP 3426689 A1
JP 2019513014 A
KR 20180120245 A
RU 2018134949 A
SG 11201807548S A
TW 201808990 A
US 2018134789 A1
WO 2017156178 A1
20 September 2018
05 February 2019
14 September 2017
21 December 2018
16 January 2019
23 May 2019
05 November 2018
08 April 2020
27 September 2018
16 March 2018
17 May 2018
14 September 2017
WO 2017087789 A1
26 May 2017
AU 2016358296 A1
CA 3003482 A1
CN 108289952 A
EP 3377103 A1
JP 2018538262 A
US 2017152316 A1
US 2018346568 A1
WO 2017087789 A1
17 May 2018
26 May 2017
17 July 2018
26 September 2018
27 December 2018
01 June 2017
06 December 2018
26 May 2017
US 2010003253 A1
07 January 2010
US 2010003253 A1
US 2011123529 A1
US 2011184151 A1
07 January 2010
26 May 2011
28 July 2011
WO 2019051102 A2
14 March 2019
AU 2018328291 A1
CA 3075034 A1
CN 111356700 A
EP 3679067 A2
KR 20200047687 A
SG 11202002089R A
TW 201920244 A
US 2019076524 A1
WO 2019051102 A2
23 April 2020
14 March 2019
30 June 2020
15 July 2020
07 May 2020
29 April 2020
01 June 2019
14 March 2019
14 March 2019
WO 2020033837 A1
13 February 2020
NONE
WO 2019051122 A2
14 March 2019
CN 111315773 A
EP 3679068 A2
WO 2019051122 A2
19 June 2020
15 July 2020
14 March 2019
WO 2019222283 A1
21 November 2019
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
16 June 2020
Date of mailing of the international search report:
14 August 2020
Authorized officer:
Wagner, René
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