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1. WO2020178713 - HYDROXYPHEOPHORBIDE COMPOUNDS, METHODS AND USES THEREOF

Publication Number WO/2020/178713
Publication Date 10.09.2020
International Application No. PCT/IB2020/051759
International Filing Date 02.03.2020
IPC
A61K 31/409 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
A61P 3/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A23L 33/00 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
A61K 36/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
C07D 487/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
22in which the condensed system contains four or more hetero rings
CPC
A23L 33/10
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A61K 31/409
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
409having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
C07D 487/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
22in which the condensed system contains four or more hetero rings
Applicants
  • CIIMAR - CENTRO INTERDISCIPLINAR DE INVESTIGAÇÃO MARINHA E AMBIENTAL [PT]/[PT]
  • UNIVERSIDADE DO PORTO [PT]/[PT]
Inventors
  • URBATZKA, Ralph
  • FREITAS, Sara
  • COSTA LEÃO, Pedro Nuno
  • SOUSA, Maria Ligia
  • ALVES REIS, Mariana
  • GONÇALVES SILVA, Natália
  • DE OLIVEIRA E VASCONCELOS, Vitor Manuel
  • RIBEIRO, Tiago
  • ROSA, Filipa
Agents
  • TEIXEIRA DE CARVALHO, Anabela
Priority Data
11534801.03.2019PT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYDROXYPHEOPHORBIDE COMPOUNDS, METHODS AND USES THEREOF
(FR) COMPOSÉS D'HYDROXYPHÉOPHORBIDE, PROCÉDÉS ET LEURS UTILISATIONS
Abstract
(EN)
The present disclosure relates to hydroxypheophorbide compounds with bioactivities towards obesity and obesity-related co-morbidities. Therefore, the present subject-matter discloses hydroxypheophorbide compounds or a pharmaceutically acceptable salt, hydrate, solvate, N-oxide, stereoisomer, diastereoisomer, enantiomer or atropisomer, polymorph for use in medicine comprising formula (I), wherein R is CnH(2n-1) and n is an entire number multiple of 5. The compound of the present disclosure may be use in the therapy or treatment of obesity, an obesity-related disorder, an obesity related disease, being overweight, an obesity-related condition, or lipid obesity disorders.
(FR)
La présente invention concerne des composés d'hydroxyphéophorbide présentant une activité biologique contre l'obésité et les comorbidités associées à l'obésité. Par conséquent, la présente invention concerne des composés d'hydroxyphéophorbide ou un sel, un hydrate, un solvate, un N-oxyde, un stéréoisomère, un diastéréoisomère, un énantiomère ou un atropisomère, un polymorphe de qualité pharmaceutique, pour utilisation dans un médicament comprenant la formule (I), dans laquelle R est CnH(2n-1) et n est un nombre entier multiple de 5. Le composé de la présente invention peut être utilisé dans la thérapie ou le traitement de l'obésité, d'un trouble lié à l'obésité, d'une maladie liée à l'obésité, d'un surpoids, d'une pathologie liée à l'obésité ou de troubles lipidiques de l'obésité.
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