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1. WO2020130084 - ANTI-INFLAMMATORY ANALGESIC EXTERNAL PREPARATION

Publication Number WO/2020/130084
Publication Date 25.06.2020
International Application No. PCT/JP2019/049856
International Filing Date 19.12.2019
IPC
A61K 31/167 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/196 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
196the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61P 23/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23Anaesthetics
02Local anaesthetics
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
Applicants
  • 株式会社 メドレックス MEDRX CO., LTD. [JP]/[JP]
Inventors
  • 川原 遥華 KAWAHARA, Haruka
  • 石橋 賢樹 ISHIBASHI, Masaki
  • 濱本 英利 HAMAMOTO, Hidetoshi
Agents
  • 山尾 憲人 YAMAO, Norihito
  • 水原 正弘 MIZUHARA, Masahiro
Priority Data
2018-23769119.12.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTI-INFLAMMATORY ANALGESIC EXTERNAL PREPARATION
(FR) PRÉPARATION EXTERNE ANALGÉSIQUE ANTI-INFLAMMATOIRE
(JA) 消炎鎮痛外用剤
Abstract
(EN)
The present invention provides: an external preparation composition including lidocaine lactate that is composed of lidocaine and a lactic acid component, and diclofenac or a salt thereof, wherein the lactic acid component is composed of a lactic acid and an alkaline-earth metal salt or an alkali metal salt of lactic acid; and an external preparation that demonstrates excellent transdermal absorption of both lidocaine and diclofenac, that realizes cutaneous permeability suitable for clinical use, and further, that exhibits improved storage stability and safety, allowing for a long shelf life.
(FR)
La présente invention concerne : une composition de préparation externe comprenant du lactate de lidocaïne qui est composé de lidocaïne et d'un composant d'acide lactique, et du diclofénac ou un sel de celui-ci, le composant d'acide lactique étant composé d'un acide lactique et d'un sel de métal alcalino-terreux ou d'un sel de métal alcalin d'acide lactique ; et une préparation externe qui présente une excellente absorption transdermique de la lidocaïne et du diclofénac, qui réalise une perméabilité cutanée appropriée pour une utilisation clinique, et qui présente en outre une stabilité et une sécurité de stockage améliorées, permettant une longue durée de conservation.
(JA)
本発明は、リドカインおよび乳酸成分からなるリドカイン乳酸塩、およびジクロフェナクまたはその塩を含む外用剤組成物であって、乳酸成分が乳酸および乳酸のアルカリ金属塩またはアルカリ土類金属塩である、外用剤組成物、ならびに、リドカインおよびジクロフェナクの経皮吸収性が共に優れ、臨床使用に適した皮膚透過性を実現し、さらに、保存安定性および安全性を向上させて、長期保存を可能にする外用剤を提供する。
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