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1. WO2020127992 - ULTRASOUND CONTRAST AGENT AND METHODS FOR USE THEREOF

Publication Number WO/2020/127992
Publication Date 25.06.2020
International Application No. PCT/EP2019/086716
International Filing Date 20.12.2019
IPC
A61K 49/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
A61K 9/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
A61K 47/24 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
Applicants
  • GE HEALTHCARE AS [NO]/[NO]
Inventors
  • HENRIKSEN, Ingrid
  • TAMNES, Eva, Krog
  • SONTUM, Per
Agents
  • BANNAN, Sally
Priority Data
1821049.221.12.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ULTRASOUND CONTRAST AGENT AND METHODS FOR USE THEREOF
(FR) AGENT DE CONTRASTE POUR ULTRASONS ET SES PROCÉDÉS D'UTILISATION
Abstract
(EN)
The present disclosure is directed to an ultrasound contrast agent comprising microbubbles of perfluorocarbon, which microbubbles are stabilised by a membrane of phospholipid; and a buffering agent; wherein the ultrasound contrast agent has a bulk pH of from about 7.5 or above, preferably about 8.5 or above.The ultrasound contrast agent is for long-term storage and is ready for use in vivo. Further disclosed is a method for preparing such an ultrasound contrast agent and methods for use of an ultrasound contrast agent in a clinical setting.
(FR)
La présente invention concerne un agent de contraste pour ultrasons qui comporte des micro-bulles de perfluorocarbone, ces micro-bulles étant stabilisées par une membrane de phospholipide, et un agent tampon, l'agent de contraste pour ultrasons ayant un pH global d'environ 7,5 ou plus, de préférence d'environ 8,5 ou plus. L'agent de contraste pour ultrasons peut être stocké à long terme et est prêt à l'utilisation in vivo. L'invention concerne en outre un procédé de préparation d'un tel agent de contraste pour ultrasons et des procédés d'utilisation d'un agent de contraste pour ultrasons en contexte clinique.
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