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1. WO2016049483 - THERAPEUTIC COMPOSITIONS FOR VIRAL-ASSOCIATED DISEASE STATES AND METHODS OF MAKING AND USING SAME

Publication Number WO/2016/049483
Publication Date 31.03.2016
International Application No. PCT/US2015/052272
International Filing Date 18.11.2015
IPC
A61M 1/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators
CPC
A61M 1/0281
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
02Blood transfusion apparatus
0281Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
A61M 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators; ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
A61M 1/3679
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; ; Extra-corporeal blood circuits
3679by absorption
A61M 1/3687
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; ; Extra-corporeal blood circuits
3687Chemical treatment
B01J 20/20
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
02comprising inorganic material
20comprising free carbon; comprising carbon obtained by carbonising processes
B01J 47/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
47Ion-exchange processes in general; Apparatus therefor
02Column or bed processes
Applicants
  • IMMUTRIX THERAPEUTICS, INC. [US]/[US]
Inventors
  • RAE, Carol A.
  • SIMONI, Jan
  • SIMONI, Grace
  • MOELLER, John F.
Agents
  • WICK PHILLIPS GOULD & MARTIN, LLP
Priority Data
62/055,39225.09.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC COMPOSITIONS FOR VIRAL-ASSOCIATED DISEASE STATES AND METHODS OF MAKING AND USING SAME
(FR) COMPOSITIONS THÉRAPEUTIQUES POUR DES ÉTATS PATHOLOGIQUES ASSOCIÉS À DES VIRUS ET DES PROCÉDÉS DE FABRICATION ET D'UTILISATION ASSOCIÉS
Abstract
(EN)
A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is from about 1:100 to produce a third filtrate; and administering the third filtrate to the subject.
(FR)
L'invention concerne un procédé comprenant l'obtention d'un fluide corporel d'un sujet; la mise en contact du fluide corporel avec un matériau adsorbant comprenant une particule de carbone synthétique (SCP) pour produire un premier filtrat ayant un niveau de médiateurs de maladie (y); la mise en contact du premier filtrat avec un matériau adsorbant comprenant le SCP et une résine échangeuse d'anions, le rapport SCP/résine échangeuse d'anions étant d'environ 0,1/100 à 100/0,1 pour produire un deuxième filtrat; la mise en contact du deuxième filtrat avec un matériau adsorbant comprenant le SCP et une résine échangeuse de cations où le rapport SCP/résine échangeuse de cations est d'environ 1/100 pour produire un troisième filtrat; et l'administration du troisième filtrat au sujet.
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