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1. WO2006071896 - EPITOPE-BASED SARS VACCINE

Publication Number WO/2006/071896
Publication Date 06.07.2006
International Application No. PCT/US2005/047144
International Filing Date 23.12.2005
Chapter 2 Demand Filed 28.04.2006
IPC
A61K 39/215 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
C12Q 1/70 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
C12N 15/50 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
C07K 16/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42against immunoglobulins (anti-idiotypic antibodies)
CPC
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 2770/20022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
20011Coronaviridae
20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applicants
  • THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN]/[CN] (AllExceptUS)
  • GUO, Zhihong [CN]/[CN] (UsOnly)
  • ZHONG, Xiaofen [CN]/[US] (UsOnly)
  • GUO, Zufeng [CN]/[CN] (UsOnly)
  • YANG, Huanghao [CN]/[CN] (UsOnly)
  • XIE, Yong [US]/[CN] (UsOnly)
Inventors
  • GUO, Zhihong
  • ZHONG, Xiaofen
  • GUO, Zufeng
  • YANG, Huanghao
  • XIE, Yong
Agents
  • CHAN, Albert, Wai-Kit
Priority Data
60/638,18823.12.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) EPITOPE-BASED SARS VACCINE
(FR) VACCIN CONTRE LE SRAS A BASE D'EPITOPES
Abstract
(EN)
This invention provides a vaccine for the infectious severe acute respiratory syndrome (SARS), which comprises antigenic epitopes from the pathogenic coronavirus. The antigenic epitopes were determined from the complementary antibodies in the plasma of convalescent SARS patients through phage display epitope mapping. These immunodominants consit of short peptide fragments distributed on various viral proteins, which includes, the spike protein, the nucleocapsid protein, the replicase 1a, and the unknown proteins 3a and 9b. Complementary antibodies targeting the immunodominant site on the spike protein effectively neutralize the coronavirus in vitro. This epitope-based vaccine avoids potential immunopathologic effects found in vaccines for other human or animal diseases since the epitopes induced safe and benificial humoral antibodies in convalescent SARS patients.
(FR)
L'invention concerne un vaccin contre le syndrome respiratoire aigu sévère (SRAS), qui comprend des épitopes antigéniques provenant du coronavirus pathogène. Les épitopes antigéniques ont été déterminés à partir des anticorps complémentaires présents dans le plasma de patients convalescents souffrant du SRAS par mappage d'épitope par affichage de phage. Ces immunodominants sont constitués de courts fragments peptidiques répartis sur diverses protéines virales, notamment, la protéine spike, la protéine de nucléocapside, la réplicase 1a, et les protéines inconnues 3a et 9b. Des anticorps complémentaires ciblant le site immunodominant sur la protéine spike neutralisent de manière efficace le coronavirus in vitro. Le vaccin à base d'épitopes de l'invention permet d'éviter l'apparition d'effets immunopathologiques potentiels produits par des vaccins utilisés pour d'autres maladies humaines ou animales étant donné que les épitopes ont induit des anticorps humoraux sûrs et bénéfiques chez des patients convalescents souffrant du SRAS.
Also published as
EP5857228
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