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1. US20080038382 - Extracts of Scutellaria for the Treatment of Sars

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Claims

1. A method for the treatment of a person afflicted with SARS-CoV infection, comprising a single botanical drug substance or one or more botanical ingredients, obtained from a species of the genus Scutellaria selected from the group consisting of Scutellaria baicalensis, S. amoena, S. barbata, S. discolor, S. hypericifolia, S. inbica, S. likiangensis, S. orthocalyx, S. rehderiana, S. scssiliflora and S. viscidula in the manufacture of a medicament for the treatment of a patient with a SARS-CoV infection.
2. The method recited in claim 1, wherein the medicament is a total extract of a Scutellaria spp.
3. The method recited in claim 1, in which the medicament further comprises one or more excipients.
4. The method recited in claim 1, wherein the substance administered is a botanical drug and is a standardised extract.
5. The method recited in claim 4, wherein the botanical drug substance from the Scutellaria spp is standardised against a marker of baicalin and/or baicalein.
6. The method recited in claim 4, wherein the standardised extract is a dried ethanolic extract.
7. The method recited in claim 4, wherein the standardised extract is a lyophilised extract.
8. The method recited in claim 1, wherein the medicament is a botanical drug.
9. The method recited in claim 8, wherein the botanical drug is packaged in a sachet.
10. The method recited in claim 9, wherein the botanical drug is packaged with a dispensing container.
11. The method recited in claim 10, wherein the dispensing container has a sealable lid.
12. The method recited in claim 3, wherein the excipients comprise one or more gellants or thickeners comprising at least one xanthum gum having a particle size distribution such that 100% by weight of the particles pass a 60 mesh sieve, 95% by weight of the particles pass a 80 mesh sieve and 70% by weight of the particles pass a 200 mesh sieve; one or more fillers; and one or more wetting agents or surfactants.
13. The method recited in claim 1, wherein the one or more botanical ingredients obtained from a species of the genus Scutellaria are plant flavenoids or synthetic equivalents thereof.
14. The method recited in claim 13, wherein the plant flavenoids are selected from the group consisting of baicalein, baicalin and wogonin.
15. The method of making a medicament, effective as an anti-viral treatment, comprising admixing a botanical raw material, a botanical drug substance or one or more botanical ingredients, obtainable from a species of the genus Scutellaria.
16. The method recited in claim 15, wherein the antiviral medicament is effective for the treatment of a patient with a positively stranded RNA viral infection.
17. The method recited in claim 15, wherein the medicament is effective for the treatment of a patient with a SARS-CoV infection.
18. A suspension dosage medicament comprising a Scutellaria spp.
19. The use of one or more botanical raw materials, one or more botanical drug substances, or one or more botanical ingredients obtainable from a species of the genus:
(a) Scutellaria;
(b) Lonicera;
(c) Forsythia; or
(d) Rabdosia
in the manufacture of a botanical drug, or dietary supplement effective for the treatment of SARS-CoV.
20. A suspension powder mixture of botanical raw materials effective as an anti-viral medicament, comprising:
Forsythia in an amount by weight relative to the total weight of all the botanical raw materials of from 30 to 70%,
Lonicera in an amount by weight relative to the total weight of all the botanical raw materials of from 12.5 to 37.5%, and
Scutellaria in an amount by weight relative to the total weight of all the botanical raw materials of from 12.5 to 37.5% and:
one or more gellants or thickeners comprising at least one xanthum gum having a particle size distribution such that 100% by weight of the particles pass a 60 mesh sieve, 95% by weight of the particles pass a 80 mesh sieve and 70% by weight of the particles pass a 200 mesh sieve; one or more fillers; and one or more wetting agents or surfactants.
21. The suspension powder mixture as claimed in claim 20 comprising standardised extracts of each of the Forsythia, Lonicera and Scutellaria species.
22. The suspension powder mixture as recited in claim 21 wherein:
the Forsythia spp is standardised against a marker of Phillyrin;
the Scutellaria spp is standardised against a marker of either or both of Baicalin and Baicalein, and the
Lonicera spp is standardised against a marker of Chlorogenic acid and/or caffeic acid.
23. A method of making a medicament for treating SARS-CoV, comprising the use of one or a plurality of baicalin, baicalein, chlorogenic acid, forsythiaside, caffeic acid and phillyrin in a medicament effective for use in the treatment of SARS-CoV.
24. A medicament effective as an anti-viral agent consisting essentially of: botanical drug substances or botanical ingredients obtainable from a species of:
(a) Scutellaria;
(b) Lonicera;
(c) Forsythia; and
(d) Rabdosia
25. A method of treating SARS-CoV comprising administering to a patient a medicament as claimed in claim 24.