NZ543467 The severe acute respiratory syndrome coronavirus

Inventors Rappuoli, Rino
Masignani, Vega
Stadler, Konrad
Gregersen, Jens-Peter
Chien, David
Han, Jang
Polo, John
Weiner, Amy
Houghton, Michael
Song, Hyun Chul
Seo, Mi Young
Donnelly, John J
Klenk, Hans Dieter
Valiante, Nicholas

Agents FB RICE

Priority Data 03 462218 10.04.2003 US
03 462418 12.04.2003 US
03 462465 11.04.2003 US
03 462748 13.04.2003 US
03 463109 14.04.2003 US
03 463460 15.04.2003 US
03 463668 16.04.2003 US
03 463971 18.04.2003 US
03 463983 17.04.2003 US
03 464838 22.04.2003 US
03 464899 22.04.2003 US
03 465273 23.04.2003 US
03 465535 24.04.2003 US
03 468312 05.05.2003 US
03 473144 22.05.2003 US
03 495024 14.08.2003 US
03 505652 23.09.2003 US
03 510781 11.10.2003 US
03 529464 11.12.2003 US
04 536177 12.01.2004 US
04 560757 07.04.2004 US

Title

(EN) The severe acute respiratory syndrome coronavirus

Abstract

(EN)

Patent 543467 Disclosed are nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. Also disclosed are methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005	from viruses
08	RNA viruses
165	Coronaviridae, e.g. avian infectious bronchitis virus

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70	involving virus or bacteriophage

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08	against material from viruses
10	from RNA viruses

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35	Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66	Microorganisms or materials therefrom
76	Viruses; Subviral particles; Bacteriophages

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
16	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

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1. NZ543467 - The severe acute respiratory syndrome coronavirus

WIPO Translate

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7	Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333	Assays involving biological materials from specific organisms or of a specific nature
005	from viruses
08	RNA viruses
165	Coronaviridae, e.g. avian infectious bronchitis virus

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
34	Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
70	characterized by effect upon binding to a cell or to an antigen
76	Antagonist effect on antigen, e.g. neutralization or inhibition of binding