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1. CN103156921 - Application of schisandra chinensis and extracts of schisandra chinensis in resisting severe acute respiratory syndrome (SARS) coronavirus infection

Office China
Application Number 201110425050.0
Application Date 13.12.2011
Publication Number 103156921
Publication Date 19.06.2013
Publication Kind A
IPC
A61K 36/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
57Magnoliaceae (Magnolia family)
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 131/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
131Containing or obtained from seeds, nuts, fruits or grains
Applicants Tianjin International Joint Academy of Biotechnology & Medicine
Inventors Rao Zihe
Yang Cheng
Lou Zhiyong
Niu Guojun
Li Yanxing
Wang Bo
Li Jinnan
Feng Jinlei
Chen Weiqiang
Wang Peng
Agents lu xin fang lingmei
Title
(EN) Application of schisandra chinensis and extracts of schisandra chinensis in resisting severe acute respiratory syndrome (SARS) coronavirus infection
(ZH) 五味子及其提取物在抗SARS冠状病毒感染中的应用
Abstract
(EN)
The invention provides the application of schisandra chinensis and extracts of the schisandra chinensis in prevention or treatment of a severe acute respiratory syndrome (SARS) coronavirus infection. When the final concentration of the schisandra chinensis is 500 micrograms per milliliter, the inhibition ratio of isolated SARS coronavirus main protease by 95% ethanol extracts of the schisandra chinensis can reach 92%, and the inhibition ratio of the SARS coronavirus main protease by ethyl acetate extracts of the 95% ethanol extracts of the schisandra chinensis is 89.1%.

(ZH)

本发明提供了五味子及其提取物在预防或者治疗SARS冠状病毒感染中的应用。在终浓度为500μg/mL时,五味子95%乙醇提取物对于离体的SARS冠状病毒主蛋白酶的抑制率达到92%,五味子95%乙醇提取物的乙酸乙酯萃取物对SARS冠状病毒主蛋白酶的抑制率为89.1%。