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1. CN111417459 - Novel drug-loaded microsphere and preparation method thereof

Office China
Application Number 201980005330.0
Application Date 05.07.2019
Publication Number 111417459
Publication Date 14.07.2020
Grant Number 111417459
Grant Date 29.12.2020
Publication Kind B
IPC
B01J 13/14
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
06by phase separation
14Polymerisation, crosslinking
B01J 13/02
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
B01J 20/26
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
22comprising organic material
26Synthetic macromolecular compounds
B01J 20/30
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
30Processes for preparing, regenerating or reactivating
B01J 20/28
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
20Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
28characterised by their form or physical properties
A61K 9/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
52Sustained or differential release type
CPC
A61K 9/501
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
501Inorganic compounds
A61K 9/5026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5026obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
A61K 31/704
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034attached to a carbocyclic compound, e.g. phloridzin
704attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
A61K 49/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61L 24/001
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
001Use of materials characterised by their function or physical properties
A61L 24/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
06obtained by reactions only involving carbon-to-carbon unsaturated bonds
Applicants GUANGZHOU ZHONGDA MEDICAL EQUIPMENT CO LTD
广州中大医疗器械有限公司
Inventors YANG YUEXIONG
杨越雄
ZHANG CHAO
张超
YANG YANG
杨阳
ZHANG YANG
张阳
HUANG DAN
黄丹
LIU JINGLING
刘景龄
LI JING
李静
WU JIEXIN
吴捷欣
Agents 广州睿金泽专利代理事务所(普通合伙) 44430
Title
(EN) Novel drug-loaded microsphere and preparation method thereof
(ZH) 一种可载药微球及其制备方法
Abstract
(EN)
The invention relates to a novel drug-loaded microsphere and a preparation method thereof. The preparation method comprises the following steps: pre-mixing a polyvinyl alcohol aqueous solution with hydroxyapatite particles, adding concentrated hydrochloric acid as a catalyst, adding a cross-linking agent glutaraldehyde to obtain a reaction solution, carrying out a pre-reaction for 3-30 seconds, dropwise adding a pre-reaction solution into a mixed oil phase containing liquid paraffin and sorbitan fatty acid ester before the pre-reaction solution is coagulated, stirring and reacting in an oil bath at 50-60 DEG C for at least 3 hours, and then filtering, washing and drying the reacted mixture to obtain the drug-loaded microspheres. The method provided by the invention is beneficial to batch production, the drug-loaded microspheres prepared by the method have high drug loading capacity and encapsulation efficiency and good slow release effect, and the hydroxyapatite particles are embeddedinto the polyvinyl alcohol after polymerization reaction, so that the drug-loaded microspheres have a certain developing function.

(ZH)
本发明公开一种新型可载药微球及其制备方法,所述制备方法是先将聚乙烯醇水溶液与羟基磷灰石微粒预混合,然后加入浓盐酸作为催化剂,再加入交联剂戊二醛得到反应液,预反应3秒‑30秒后,在预反应液凝结前将预反应液滴加到包括液体石蜡和失水山梨糖醇脂肪酸酯的混合油相中,在50℃‑60℃下油浴搅拌反应至少3小时,然后对反应后的混合物进行过滤、洗涤、干燥,即得可载药微球。本发明所述方法有利于批量生产,且所述方法制备得到的可载药微球具有较高的载药量和包封率,缓释效果好,而且羟基磷灰石微粒在聚合反应后嵌入聚乙烯醇中,使得可载药微球具有一定显影功能。

Also published as
CN201980005330.0