AU2009201478 The severe acute respiratory syndrome coronavirus

Inventors Chien, David
Donnelly, John J.
Gregersen, Jens-Peter
Han, Jang
Houghton, Michael
Klenk, Hans Dieter
Masignani, Vega
Polo, John
Rappuoli, Rino
Seo, Mi Young
Song, Hyun Chul
Stadler, Konrad
Valiante, Nicholas
Weiner, Amy

Agents FB Rice Pty Ltd

Priority Data 60/462,218 10.04.2003 US
60/462,418 12.04.2003 US
60/462,465 11.04.2003 US
60/462,748 13.04.2003 US
60/463,109 14.04.2003 US
60/463,460 15.04.2003 US
60/463,668 16.04.2003 US
60/463,971 18.04.2003 US
60/463,983 17.04.2003 US
60/464,838 22.04.2003 US
60/464,899 22.04.2003 US
60/465,273 23.04.2003 US
60/465,535 24.04.2003 US
60/468,312 05.05.2003 US
60/473,144 22.05.2003 US
60/495,024 14.08.2003 US
60/505,652 23.09.2003 US
60/510,781 11.10.2003 US
60/529,464 11.12.2003 US
60/536,177 12.01.2004 US
60/560,757 07.04.2004 US

Title

(EN) The severe acute respiratory syndrome coronavirus

Abstract

(EN)

An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.

Also published as

EP1618127

CN1829736

CA2522379

ES2529736

AU2004230485

WO/2004/092360

US20060257852

JP2006510100

NZ543467

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005	from viruses
08	RNA viruses
165	Coronaviridae, e.g. avian infectious bronchitis virus

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35	Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66	Microorganisms or materials therefrom
76	Viruses; Subviral particles; Bacteriophages

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
16	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
12	Viral antigens
215	Coronaviridae, e.g. avian infectious bronchitis virus

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
16	Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08	against material from viruses
10	from RNA viruses

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1. AU2009201478 - The severe acute respiratory syndrome coronavirus

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C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7	Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04	Inactivation or attenuation; Producing viral sub-units
06	by chemical treatment

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70	involving virus or bacteriophage

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333	Assays involving biological materials from specific organisms or of a specific nature
005	from viruses
08	RNA viruses
165	Coronaviridae, e.g. avian infectious bronchitis virus

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
30	characterized by aspects of specificity or valency
34	Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2317	Immunoglobulins specific features
70	characterized by effect upon binding to a cell or to an antigen
76	Antagonist effect on antigen, e.g. neutralization or inhibition of binding